Effect of Povidone Iodine Versus Chlorhexidine Mouthwash on Oral Mucositis among Cancer Patients
Introduction: Radiation therapy and chemotherapy are the standard treatment given for cancer, which leads to the variety of adverse effects of which Oral Mucositis (OM) is one of the common side-effects. It is responsible for patient discomfort and decreases their level of functioning. Both Chlo...
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
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| Acceso en línea: | https://doaj.org/article/f1896a5e2b2643f9b30c4ec277d95424 |
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| Sumario: | Introduction: Radiation therapy and chemotherapy are the
standard treatment given for cancer, which leads to the variety
of adverse effects of which Oral Mucositis (OM) is one of the
common side-effects. It is responsible for patient discomfort
and decreases their level of functioning. Both Chlorhexidine and
Povidone Iodine have got antimicrobial and antifungal activity
which decreases the severity of mucositis.
Aim: To compare the effectiveness of Povidone Iodine and
Chlorhexidine mouthwash on OM among cancer patients
undergoing radiation therapy or chemotherapy.
Materials and Methods: A prospective observational study was
conducted in the tertiary care hospital of Mangaluru, Karnataka,
India for the duration of one year and three months from
December 2015-March 2017. Fifty cancer subjects aged between
25 to 65 years and who developed OM after radiation therapy or
chemotherapy were selected by purposive sampling technique.
Data were collected using the demographic profile, clinical
proforma and World Health Organisation (WHO) OM grading
scale (2004) from 19.09.2016 to 17.12.2016. Experimental group I
received 10 mL of diluted Povidone Iodine mouthwash and group II
received 10 mL of diluted chlorhexidine mouthwash. Level of
OM in the group I and group II were assessed on the 1st, 3rd, 5th
and 7th day using WHO OM grading scale (2004). The data were
analysed by descriptive and inferential statistics (Wilcoxon signedrank test, Mann-Whitney U test, Repeated measures ANOVA)
using SPSS version 16.0.
Results: Among the 50 cancer subjects, majority 30 (60%) were
in the age group between 55-64 years and majority 35 (70%) were
receiving radiation therapy. On day seven, in the group I (Povidone
Iodine) majority 14 (56%) subjects had mild level of mucositis
whereas in the group II (Chlorhexidine) majority 14 (56%) subjects
had moderate mucositis. Comparison of the effect of Povidone
Iodine and Chlorhexidine mouthwash using Friedman’s ANOVA
showed that there was a difference in the level of mucositis
(p<0.05) at 5% level of significance among two groups. The
study findings also revealed a difference in the level of mucositis
between day 1 to day 3, 5 and 7 (Mann-Whitney U test) (p<0.05)
in both the groups.
Conclusion: Povidone Iodine mouth wash was more effective than
Chlorhexidine mouthwashes in reducing OM, and the patients
were more comfortable after the use of the mouthwash. |
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