Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task

Abstract Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is not well characterized. In the present stu...

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Autores principales:	A. Ezequiel Pereyra, Camilo J. Mininni, B. Silvano Zanutto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f18bb8c230f0445baa581cfd910d6fd1
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spelling	oai:doaj.org-article:f18bb8c230f0445baa581cfd910d6fd12021-12-02T18:34:07ZInformation capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task10.1038/s41598-021-93313-62045-2322https://doaj.org/article/f18bb8c230f0445baa581cfd910d6fd12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93313-6https://doaj.org/toc/2045-2322Abstract Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is not well characterized. In the present study, we made single neuron extracellular recordings in the mPFC of rats performing an operant conditioning task, and analyzed the effect of systemic administration of fluoxetine (a selective serotonin reuptake inhibitor) on the information encoded in the firing activity of the neural population. Chronic (longer than 15 days), but not acute (less than 15 days), fluoxetine administration reduced the firing rate of mPFC neurons. Moreover, fluoxetine treatment enhanced pairwise entropy but diminished noise correlation and redundancy in the information encoded, thus showing how mPFC differentially encodes information as a function of 5-HT bioavailability. Information about the occurrence of the reward-predictive stimulus was maximized during reward consumption, around 3 to 4 s after the presentation of the cue, and it was higher under chronic fluoxetine treatment. However, the encoded information was less robust to noise corruption when compared to control conditions.A. Ezequiel PereyraCamilo J. MininniB. Silvano ZanuttoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Ezequiel Pereyra Camilo J. Mininni B. Silvano Zanutto Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
description	Abstract Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is not well characterized. In the present study, we made single neuron extracellular recordings in the mPFC of rats performing an operant conditioning task, and analyzed the effect of systemic administration of fluoxetine (a selective serotonin reuptake inhibitor) on the information encoded in the firing activity of the neural population. Chronic (longer than 15 days), but not acute (less than 15 days), fluoxetine administration reduced the firing rate of mPFC neurons. Moreover, fluoxetine treatment enhanced pairwise entropy but diminished noise correlation and redundancy in the information encoded, thus showing how mPFC differentially encodes information as a function of 5-HT bioavailability. Information about the occurrence of the reward-predictive stimulus was maximized during reward consumption, around 3 to 4 s after the presentation of the cue, and it was higher under chronic fluoxetine treatment. However, the encoded information was less robust to noise corruption when compared to control conditions.
format	article
author	A. Ezequiel Pereyra Camilo J. Mininni B. Silvano Zanutto
author_facet	A. Ezequiel Pereyra Camilo J. Mininni B. Silvano Zanutto
author_sort	A. Ezequiel Pereyra
title	Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
title_short	Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
title_full	Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
title_fullStr	Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
title_full_unstemmed	Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
title_sort	information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f18bb8c230f0445baa581cfd910d6fd1
work_keys_str_mv	AT aezequielpereyra informationcapacityandrobustnessofencodinginthemedialprefrontalcortexaremodulatedbythebioavailabilityofserotoninandthetimeelapsedfromthecueduringarewarddriventask AT camilojmininni informationcapacityandrobustnessofencodinginthemedialprefrontalcortexaremodulatedbythebioavailabilityofserotoninandthetimeelapsedfromthecueduringarewarddriventask AT bsilvanozanutto informationcapacityandrobustnessofencodinginthemedialprefrontalcortexaremodulatedbythebioavailabilityofserotoninandthetimeelapsedfromthecueduringarewarddriventask
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Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task

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