NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.

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Autores principales: Xiaoguang Li, Zhida Liu, Anli Zhang, Chuanhui Han, Aijun Shen, Lingxiang Jiang, David A. Boothman, Jian Qiao, Yang Wang, Xiumei Huang, Yang-Xin Fu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f18e4e20985045188e6e4ba9bb61cc6d
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spelling oai:doaj.org-article:f18e4e20985045188e6e4ba9bb61cc6d2021-12-02T15:35:59ZNQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance10.1038/s41467-019-11238-12041-1723https://doaj.org/article/f18e4e20985045188e6e4ba9bb61cc6d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11238-1https://doaj.org/toc/2041-1723Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.Xiaoguang LiZhida LiuAnli ZhangChuanhui HanAijun ShenLingxiang JiangDavid A. BoothmanJian QiaoYang WangXiumei HuangYang-Xin FuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaoguang Li
Zhida Liu
Anli Zhang
Chuanhui Han
Aijun Shen
Lingxiang Jiang
David A. Boothman
Jian Qiao
Yang Wang
Xiumei Huang
Yang-Xin Fu
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
description Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.
format article
author Xiaoguang Li
Zhida Liu
Anli Zhang
Chuanhui Han
Aijun Shen
Lingxiang Jiang
David A. Boothman
Jian Qiao
Yang Wang
Xiumei Huang
Yang-Xin Fu
author_facet Xiaoguang Li
Zhida Liu
Anli Zhang
Chuanhui Han
Aijun Shen
Lingxiang Jiang
David A. Boothman
Jian Qiao
Yang Wang
Xiumei Huang
Yang-Xin Fu
author_sort Xiaoguang Li
title NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
title_short NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
title_full NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
title_fullStr NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
title_full_unstemmed NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
title_sort nqo1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f18e4e20985045188e6e4ba9bb61cc6d
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