NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.

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Bibliographic Details
Main Authors: Xiaoguang Li, Zhida Liu, Anli Zhang, Chuanhui Han, Aijun Shen, Lingxiang Jiang, David A. Boothman, Jian Qiao, Yang Wang, Xiumei Huang, Yang-Xin Fu
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/f18e4e20985045188e6e4ba9bb61cc6d
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