Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic ruptur...

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Autores principales:	Frederick Eyerer, Juli-Anne Gardner, Katherine A. Devitt
Formato:	article
Lenguaje:	EN
Publicado:	University of São Paulo 2021
Materias:	Lymphoma, Mantle-Cell Splenic Rupture Cyclin D Lymphoma, Malignant Medicine R Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/f191eef4cddc41b69d8430cdd08020e8
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spelling	oai:doaj.org-article:f191eef4cddc41b69d8430cdd08020e82021-11-19T04:03:38ZMantle cell lymphoma presenting with lethal atraumatic splenic rupture2236-1960https://doaj.org/article/f191eef4cddc41b69d8430cdd08020e82021-11-01T00:00:00Zhttps://www.revistas.usp.br/autopsy/article/view/192681https://doaj.org/toc/2236-1960 Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture. Frederick EyererJuli-Anne GardnerKatherine A. DevittUniversity of São PauloarticleLymphoma, Mantle-CellSplenic RuptureCyclin DLymphoma, MalignantMedicineRInternal medicineRC31-1245ENAutopsy and Case Reports, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lymphoma, Mantle-Cell Splenic Rupture Cyclin D Lymphoma, Malignant Medicine R Internal medicine RC31-1245
spellingShingle	Lymphoma, Mantle-Cell Splenic Rupture Cyclin D Lymphoma, Malignant Medicine R Internal medicine RC31-1245 Frederick Eyerer Juli-Anne Gardner Katherine A. Devitt Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
description	Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
format	article
author	Frederick Eyerer Juli-Anne Gardner Katherine A. Devitt
author_facet	Frederick Eyerer Juli-Anne Gardner Katherine A. Devitt
author_sort	Frederick Eyerer
title	Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_short	Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_full	Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_fullStr	Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_full_unstemmed	Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_sort	mantle cell lymphoma presenting with lethal atraumatic splenic rupture
publisher	University of São Paulo
publishDate	2021
url	https://doaj.org/article/f191eef4cddc41b69d8430cdd08020e8
work_keys_str_mv	AT frederickeyerer mantlecelllymphomapresentingwithlethalatraumaticsplenicrupture AT juliannegardner mantlecelllymphomapresentingwithlethalatraumaticsplenicrupture AT katherineadevitt mantlecelllymphomapresentingwithlethalatraumaticsplenicrupture
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Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

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