The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats

Abstract Zoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The exp...

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Autores principales:	Fátima Regina Nunes de Sousa, Vanessa Costa de Sousa Ferreira, Conceição da Silva Martins, Hugo Victor Dantas, Frederico Barbosa de Sousa, Virgínia Cláudia Carneiro Girão-Carmona, Paula Goes, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1923cee5dfd4d1eaa2c338788592931
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spelling	oai:doaj.org-article:f1923cee5dfd4d1eaa2c3387885929312021-12-02T14:20:43ZThe effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats10.1038/s41598-021-87375-92045-2322https://doaj.org/article/f1923cee5dfd4d1eaa2c3387885929312021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87375-9https://doaj.org/toc/2045-2322Abstract Zoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the concentration of 0.2 mg/kg [ZA (0.2)] or 1.0 mg/kg [ZA (1.0)]. The animals were subjected to i.v (dorsal penile vein) administrations of ZA or saline solution, on days 0, 7, 14 and 42. Under anesthesia, NiTi springs were installed in the first left maxillary molar with 50gf allowing the OTM, except for the negative control group (N) for mesial movement of the left first maxillary teeth. The animals were sacrificed and maxillae were removed for macroscopic and histopathological analyzes, scanning electron microscopy, computerized microtomography and confocal microscopy. Treatment with ZA decreased the OTM and the number of osteoclasts and loss of alveolar bone when compared to the naive and saline groups. Reduction of radicular resorption, increased necrotic areas and reduced vascularization in the periodontal ligament were observed in the ZA groups. ZA interferes with OTM and presents anti-resorptive effects on bone and dental tissues associated with a decreased vascularization, without osteonecrosis.Fátima Regina Nunes de SousaVanessa Costa de Sousa FerreiraConceição da Silva MartinsHugo Victor DantasFrederico Barbosa de SousaVirgínia Cláudia Carneiro Girão-CarmonaPaula GoesGerly Anne de Castro BritoRenata Ferreira de Carvalho LeitãoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fátima Regina Nunes de Sousa Vanessa Costa de Sousa Ferreira Conceição da Silva Martins Hugo Victor Dantas Frederico Barbosa de Sousa Virgínia Cláudia Carneiro Girão-Carmona Paula Goes Gerly Anne de Castro Brito Renata Ferreira de Carvalho Leitão The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
description	Abstract Zoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the concentration of 0.2 mg/kg [ZA (0.2)] or 1.0 mg/kg [ZA (1.0)]. The animals were subjected to i.v (dorsal penile vein) administrations of ZA or saline solution, on days 0, 7, 14 and 42. Under anesthesia, NiTi springs were installed in the first left maxillary molar with 50gf allowing the OTM, except for the negative control group (N) for mesial movement of the left first maxillary teeth. The animals were sacrificed and maxillae were removed for macroscopic and histopathological analyzes, scanning electron microscopy, computerized microtomography and confocal microscopy. Treatment with ZA decreased the OTM and the number of osteoclasts and loss of alveolar bone when compared to the naive and saline groups. Reduction of radicular resorption, increased necrotic areas and reduced vascularization in the periodontal ligament were observed in the ZA groups. ZA interferes with OTM and presents anti-resorptive effects on bone and dental tissues associated with a decreased vascularization, without osteonecrosis.
format	article
author	Fátima Regina Nunes de Sousa Vanessa Costa de Sousa Ferreira Conceição da Silva Martins Hugo Victor Dantas Frederico Barbosa de Sousa Virgínia Cláudia Carneiro Girão-Carmona Paula Goes Gerly Anne de Castro Brito Renata Ferreira de Carvalho Leitão
author_facet	Fátima Regina Nunes de Sousa Vanessa Costa de Sousa Ferreira Conceição da Silva Martins Hugo Victor Dantas Frederico Barbosa de Sousa Virgínia Cláudia Carneiro Girão-Carmona Paula Goes Gerly Anne de Castro Brito Renata Ferreira de Carvalho Leitão
author_sort	Fátima Regina Nunes de Sousa
title	The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
title_short	The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
title_full	The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
title_fullStr	The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
title_full_unstemmed	The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
title_sort	effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f1923cee5dfd4d1eaa2c338788592931
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The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats

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