Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms

Mycotoxins are one of the most dangerous food and feed contaminants, hence they have significant influence on human and animal health. This study reviews the information reported over the last few years on the toxic effects of the most relevant and studied <i>Fusarium</i> toxins and thei...

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Autores principales:	Adam Pierzgalski, Marcin Bryła, Joanna Kanabus, Marta Modrzewska, Grażyna Podolska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	toxicity <i>Fusarium</i> toxins modified mycotoxins metabolism deoxynivalenol T-2 toxin zearalenone Medicine R
Acceso en línea:	https://doaj.org/article/f1952932bdc14d10978d6b7b6b2b9e97
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spelling	oai:doaj.org-article:f1952932bdc14d10978d6b7b6b2b9e972021-11-25T19:08:41ZUpdated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms10.3390/toxins131107682072-6651https://doaj.org/article/f1952932bdc14d10978d6b7b6b2b9e972021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/768https://doaj.org/toc/2072-6651Mycotoxins are one of the most dangerous food and feed contaminants, hence they have significant influence on human and animal health. This study reviews the information reported over the last few years on the toxic effects of the most relevant and studied <i>Fusarium</i> toxins and their modified forms. Deoxynivalenol (DON) and its metabolites can induce intracellular oxidative stress, resulting in DNA damage. Recent studies have also revealed the capability of DON and its metabolites to disturb the cell cycle and alter amino acid expression. Several studies have attempted to explore the mechanism of action of T-2 and HT-2 toxins in anorexia induction. Among other findings, two neurotransmitters associated with this process have been identified, namely substance P and serotonin (5-hydroxytryptamine). For zearalenone (ZEN) and its metabolites, the literature points out that, in addition to their generally acknowledged estrogenic and oxidative potentials, they can also modify DNA by altering methylation patterns and histone acetylation. The ability of the compounds to induce alterations in the expression of major metabolic genes suggests that these compounds can contribute to the development of numerous metabolic diseases, including type 2 diabetes.Adam PierzgalskiMarcin BryłaJoanna KanabusMarta ModrzewskaGrażyna PodolskaMDPI AGarticletoxicity<i>Fusarium</i> toxinsmodified mycotoxins metabolismdeoxynivalenolT-2 toxinzearalenoneMedicineRENToxins, Vol 13, Iss 768, p 768 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	toxicity <i>Fusarium</i> toxins modified mycotoxins metabolism deoxynivalenol T-2 toxin zearalenone Medicine R
spellingShingle	toxicity <i>Fusarium</i> toxins modified mycotoxins metabolism deoxynivalenol T-2 toxin zearalenone Medicine R Adam Pierzgalski Marcin Bryła Joanna Kanabus Marta Modrzewska Grażyna Podolska Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
description	Mycotoxins are one of the most dangerous food and feed contaminants, hence they have significant influence on human and animal health. This study reviews the information reported over the last few years on the toxic effects of the most relevant and studied <i>Fusarium</i> toxins and their modified forms. Deoxynivalenol (DON) and its metabolites can induce intracellular oxidative stress, resulting in DNA damage. Recent studies have also revealed the capability of DON and its metabolites to disturb the cell cycle and alter amino acid expression. Several studies have attempted to explore the mechanism of action of T-2 and HT-2 toxins in anorexia induction. Among other findings, two neurotransmitters associated with this process have been identified, namely substance P and serotonin (5-hydroxytryptamine). For zearalenone (ZEN) and its metabolites, the literature points out that, in addition to their generally acknowledged estrogenic and oxidative potentials, they can also modify DNA by altering methylation patterns and histone acetylation. The ability of the compounds to induce alterations in the expression of major metabolic genes suggests that these compounds can contribute to the development of numerous metabolic diseases, including type 2 diabetes.
format	article
author	Adam Pierzgalski Marcin Bryła Joanna Kanabus Marta Modrzewska Grażyna Podolska
author_facet	Adam Pierzgalski Marcin Bryła Joanna Kanabus Marta Modrzewska Grażyna Podolska
author_sort	Adam Pierzgalski
title	Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
title_short	Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
title_full	Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
title_fullStr	Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
title_full_unstemmed	Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms
title_sort	updated review of the toxicity of selected <i>fusarium</i> toxins and their modified forms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1952932bdc14d10978d6b7b6b2b9e97
work_keys_str_mv	AT adampierzgalski updatedreviewofthetoxicityofselectedifusariumitoxinsandtheirmodifiedforms AT marcinbryła updatedreviewofthetoxicityofselectedifusariumitoxinsandtheirmodifiedforms AT joannakanabus updatedreviewofthetoxicityofselectedifusariumitoxinsandtheirmodifiedforms AT martamodrzewska updatedreviewofthetoxicityofselectedifusariumitoxinsandtheirmodifiedforms AT grazynapodolska updatedreviewofthetoxicityofselectedifusariumitoxinsandtheirmodifiedforms
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Updated Review of the Toxicity of Selected <i>Fusarium</i> Toxins and Their Modified Forms

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