Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli

It is unclear how noise in gene expression propagates to phenotypic heterogeneity in clonal bacterial populations. Here, the authors explore how variability in central sugar metabolism in E. coli can mediate and promote population diversification.

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Autores principales:	Diego Antonio Fernandez Fuentes, Pablo Manfredi, Urs Jenal, Mattia Zampieri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f19647490bf845ada590efc8190969d3
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spelling	oai:doaj.org-article:f19647490bf845ada590efc8190969d32021-12-02T15:00:24ZPareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli10.1038/s41467-021-23522-02041-1723https://doaj.org/article/f19647490bf845ada590efc8190969d32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23522-0https://doaj.org/toc/2041-1723It is unclear how noise in gene expression propagates to phenotypic heterogeneity in clonal bacterial populations. Here, the authors explore how variability in central sugar metabolism in E. coli can mediate and promote population diversification.Diego Antonio Fernandez FuentesPablo ManfrediUrs JenalMattia ZampieriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diego Antonio Fernandez Fuentes Pablo Manfredi Urs Jenal Mattia Zampieri Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
description	It is unclear how noise in gene expression propagates to phenotypic heterogeneity in clonal bacterial populations. Here, the authors explore how variability in central sugar metabolism in E. coli can mediate and promote population diversification.
format	article
author	Diego Antonio Fernandez Fuentes Pablo Manfredi Urs Jenal Mattia Zampieri
author_facet	Diego Antonio Fernandez Fuentes Pablo Manfredi Urs Jenal Mattia Zampieri
author_sort	Diego Antonio Fernandez Fuentes
title	Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
title_short	Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
title_full	Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
title_fullStr	Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
title_full_unstemmed	Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli
title_sort	pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in escherichia coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f19647490bf845ada590efc8190969d3
work_keys_str_mv	AT diegoantoniofernandezfuentes paretooptimalitybetweengrowthrateandlagtimecouplesmetabolicnoisetophenotypicheterogeneityinescherichiacoli AT pablomanfredi paretooptimalitybetweengrowthrateandlagtimecouplesmetabolicnoisetophenotypicheterogeneityinescherichiacoli AT ursjenal paretooptimalitybetweengrowthrateandlagtimecouplesmetabolicnoisetophenotypicheterogeneityinescherichiacoli AT mattiazampieri paretooptimalitybetweengrowthrateandlagtimecouplesmetabolicnoisetophenotypicheterogeneityinescherichiacoli
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Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli

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