Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
Ingression of cells from the lateral plate mesoderm (LPM) initiates gonad differentiation but how these events are triggered is unclear. Here, the authors show that gonadal progenitor cells at the ventromedial LPM initiate gonadogenesis, and are activated by Hedgehog and BMP4 signalling.
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| Auteurs principaux: | , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f1999fb2e6b6481e98f070e77e3648c6 |
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| Résumé: | Ingression of cells from the lateral plate mesoderm (LPM) initiates gonad differentiation but how these events are triggered is unclear. Here, the authors show that gonadal progenitor cells at the ventromedial LPM initiate gonadogenesis, and are activated by Hedgehog and BMP4 signalling. |
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