Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos

Ingression of cells from the lateral plate mesoderm (LPM) initiates gonad differentiation but how these events are triggered is unclear. Here, the authors show that gonadal progenitor cells at the ventromedial LPM initiate gonadogenesis, and are activated by Hedgehog and BMP4 signalling.

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Bibliographic Details
Main Authors:	Takashi Yoshino, Hidetaka Murai, Daisuke Saito
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/f1999fb2e6b6481e98f070e77e3648c6
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spelling	oai:doaj.org-article:f1999fb2e6b6481e98f070e77e3648c62021-12-02T14:40:14ZHedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos10.1038/ncomms125612041-1723https://doaj.org/article/f1999fb2e6b6481e98f070e77e3648c62016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12561https://doaj.org/toc/2041-1723Ingression of cells from the lateral plate mesoderm (LPM) initiates gonad differentiation but how these events are triggered is unclear. Here, the authors show that gonadal progenitor cells at the ventromedial LPM initiate gonadogenesis, and are activated by Hedgehog and BMP4 signalling.Takashi YoshinoHidetaka MuraiDaisuke SaitoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takashi Yoshino Hidetaka Murai Daisuke Saito Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
description	Ingression of cells from the lateral plate mesoderm (LPM) initiates gonad differentiation but how these events are triggered is unclear. Here, the authors show that gonadal progenitor cells at the ventromedial LPM initiate gonadogenesis, and are activated by Hedgehog and BMP4 signalling.
format	article
author	Takashi Yoshino Hidetaka Murai Daisuke Saito
author_facet	Takashi Yoshino Hidetaka Murai Daisuke Saito
author_sort	Takashi Yoshino
title	Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
title_short	Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
title_full	Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
title_fullStr	Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
title_full_unstemmed	Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
title_sort	hedgehog–bmp signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f1999fb2e6b6481e98f070e77e3648c6
work_keys_str_mv	AT takashiyoshino hedgehogbmpsignallingestablishesdorsoventralpatterninginlateralplatemesodermtotriggergonadogenesisinchickenembryos AT hidetakamurai hedgehogbmpsignallingestablishesdorsoventralpatterninginlateralplatemesodermtotriggergonadogenesisinchickenembryos AT daisukesaito hedgehogbmpsignallingestablishesdorsoventralpatterninginlateralplatemesodermtotriggergonadogenesisinchickenembryos
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Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos

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