Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment

Objective: To clarify the effects of escitalopram on sleep EEG power in patients with Major depressive disorder (MDD).Method: Polysomnography (PSG) was detected overnight, and blood samples were collected at 4 h intervals over 24 h from 13 male healthy controls and 13 male MDD patients before and af...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xue-Qin Wang, De-Quan Wang, Yan-Ping Bao, Jia-Jia Liu, Jie Chen, Shao-Wei Wu, Hsuan-Nu Luk, Ling Yu, Wei Sun, Yong Yang, Xue-Hua Wang, Lin Lu, Jia-Hui Deng, Su-Xia Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	major depressive disorder polysomnography escitalopram melatonin sleep EEG power Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f199aa0a50894012a2412486a3a6d6fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f199aa0a50894012a2412486a3a6d6fb
record_format	dspace
spelling	oai:doaj.org-article:f199aa0a50894012a2412486a3a6d6fb2021-11-12T05:21:22ZPreliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment1664-064010.3389/fpsyt.2021.736318https://doaj.org/article/f199aa0a50894012a2412486a3a6d6fb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.736318/fullhttps://doaj.org/toc/1664-0640Objective: To clarify the effects of escitalopram on sleep EEG power in patients with Major depressive disorder (MDD).Method: Polysomnography (PSG) was detected overnight, and blood samples were collected at 4 h intervals over 24 h from 13 male healthy controls and 13 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included plasma melatonin levels, sleep architecture, and the sleep EEG power ratio.Results: Compared with healthy controls, MDD patients presented abnormalities in the diurnal rhythm of melatonin secretion, including peak phase delayed 3 h and a decrease in plasma melatonin levels at night and an increase at daytime, accompanied by sleep disturbances, a decrease in low-frequency bands and an increase in high-frequency bands, and the dominant right-side brain activity. Several of these abnormalities (abnormalities in the diurnal rhythm of melatonin secretion, partial sleep architecture parameters) persisted for at least the 8-week testing period.Conclusions: Eight weeks of treatment with escitalopram significantly improved subjective sleep perception and depressive symptoms of patients with MDD, and partially improved objective sleep parameters, while the improvement of circadian rhythm of melatonin was limited.Xue-Qin WangDe-Quan WangYan-Ping BaoJia-Jia LiuJie ChenShao-Wei WuShao-Wei WuHsuan-Nu LukLing YuWei SunYong YangXue-Hua WangLin LuLin LuLin LuJia-Hui DengSu-Xia LiSu-Xia LiFrontiers Media S.A.articlemajor depressive disorderpolysomnographyescitaloprammelatoninsleep EEG powerPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder polysomnography escitalopram melatonin sleep EEG power Psychiatry RC435-571
spellingShingle	major depressive disorder polysomnography escitalopram melatonin sleep EEG power Psychiatry RC435-571 Xue-Qin Wang De-Quan Wang Yan-Ping Bao Jia-Jia Liu Jie Chen Shao-Wei Wu Shao-Wei Wu Hsuan-Nu Luk Ling Yu Wei Sun Yong Yang Xue-Hua Wang Lin Lu Lin Lu Lin Lu Jia-Hui Deng Su-Xia Li Su-Xia Li Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
description	Objective: To clarify the effects of escitalopram on sleep EEG power in patients with Major depressive disorder (MDD).Method: Polysomnography (PSG) was detected overnight, and blood samples were collected at 4 h intervals over 24 h from 13 male healthy controls and 13 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included plasma melatonin levels, sleep architecture, and the sleep EEG power ratio.Results: Compared with healthy controls, MDD patients presented abnormalities in the diurnal rhythm of melatonin secretion, including peak phase delayed 3 h and a decrease in plasma melatonin levels at night and an increase at daytime, accompanied by sleep disturbances, a decrease in low-frequency bands and an increase in high-frequency bands, and the dominant right-side brain activity. Several of these abnormalities (abnormalities in the diurnal rhythm of melatonin secretion, partial sleep architecture parameters) persisted for at least the 8-week testing period.Conclusions: Eight weeks of treatment with escitalopram significantly improved subjective sleep perception and depressive symptoms of patients with MDD, and partially improved objective sleep parameters, while the improvement of circadian rhythm of melatonin was limited.
format	article
author	Xue-Qin Wang De-Quan Wang Yan-Ping Bao Jia-Jia Liu Jie Chen Shao-Wei Wu Shao-Wei Wu Hsuan-Nu Luk Ling Yu Wei Sun Yong Yang Xue-Hua Wang Lin Lu Lin Lu Lin Lu Jia-Hui Deng Su-Xia Li Su-Xia Li
author_facet	Xue-Qin Wang De-Quan Wang Yan-Ping Bao Jia-Jia Liu Jie Chen Shao-Wei Wu Shao-Wei Wu Hsuan-Nu Luk Ling Yu Wei Sun Yong Yang Xue-Hua Wang Lin Lu Lin Lu Lin Lu Jia-Hui Deng Su-Xia Li Su-Xia Li
author_sort	Xue-Qin Wang
title	Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
title_short	Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
title_full	Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
title_fullStr	Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
title_full_unstemmed	Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment
title_sort	preliminary study on changes of sleep eeg power and plasma melatonin in male patients with major depressive disorder after 8 weeks treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f199aa0a50894012a2412486a3a6d6fb
work_keys_str_mv	AT xueqinwang preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT dequanwang preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT yanpingbao preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT jiajialiu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT jiechen preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT shaoweiwu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT shaoweiwu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT hsuannuluk preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT lingyu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT weisun preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT yongyang preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT xuehuawang preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT linlu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT linlu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT linlu preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT jiahuideng preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT suxiali preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment AT suxiali preliminarystudyonchangesofsleepeegpowerandplasmamelatonininmalepatientswithmajordepressivedisorderafter8weekstreatment
_version_	1718431203786227712

Preliminary Study on Changes of Sleep EEG Power and Plasma Melatonin in Male Patients With Major Depressive Disorder After 8 Weeks Treatment

Ejemplares similares