Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management

Background: Behcet’s disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age-groups. There are many variations of BD; however, intestin...

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Autores principales:	Anthony Nguyen, Shubhra Upadhyay, Muhammad Ali Javaid, Abdul Moiz Qureshi, Shahan Haseeb, Nismat Javed, Christopher Cormier, Asif Farooq, Abu Baker Sheikh
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	inflammatory vascular disorder management pathogenesis behcet’s disease gastrointestinal involvement Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f19abc3a0ea7412781ffa470a6fe05c8
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spelling	oai:doaj.org-article:f19abc3a0ea7412781ffa470a6fe05c82021-12-02T12:40:23ZBehcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management2296-94032296-936510.1159/000520696https://doaj.org/article/f19abc3a0ea7412781ffa470a6fe05c82021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520696https://doaj.org/toc/2296-9403https://doaj.org/toc/2296-9365Background: Behcet’s disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age-groups. There are many variations of BD; however, intestinal BD is not only more common but has many signs and symptoms. Summary: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability, and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. Key Messages: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses, and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations, and creating robust algorithms.Anthony NguyenShubhra UpadhyayMuhammad Ali JavaidAbdul Moiz QureshiShahan HaseebNismat JavedChristopher CormierAsif FarooqAbu Baker SheikhKarger Publishersarticleinflammatory vascular disordermanagementpathogenesisbehcet’s diseasegastrointestinal involvementDiseases of the digestive system. GastroenterologyRC799-869ENInflammatory Intestinal Diseases, Vol 6, Iss 4, Pp 175-185 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory vascular disorder management pathogenesis behcet’s disease gastrointestinal involvement Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	inflammatory vascular disorder management pathogenesis behcet’s disease gastrointestinal involvement Diseases of the digestive system. Gastroenterology RC799-869 Anthony Nguyen Shubhra Upadhyay Muhammad Ali Javaid Abdul Moiz Qureshi Shahan Haseeb Nismat Javed Christopher Cormier Asif Farooq Abu Baker Sheikh Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
description	Background: Behcet’s disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age-groups. There are many variations of BD; however, intestinal BD is not only more common but has many signs and symptoms. Summary: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability, and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. Key Messages: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses, and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations, and creating robust algorithms.
format	article
author	Anthony Nguyen Shubhra Upadhyay Muhammad Ali Javaid Abdul Moiz Qureshi Shahan Haseeb Nismat Javed Christopher Cormier Asif Farooq Abu Baker Sheikh
author_facet	Anthony Nguyen Shubhra Upadhyay Muhammad Ali Javaid Abdul Moiz Qureshi Shahan Haseeb Nismat Javed Christopher Cormier Asif Farooq Abu Baker Sheikh
author_sort	Anthony Nguyen
title	Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
title_short	Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
title_full	Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
title_fullStr	Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
title_full_unstemmed	Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management
title_sort	behcet’s disease: an in-depth review about pathogenesis, gastrointestinal manifestations, and management
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/f19abc3a0ea7412781ffa470a6fe05c8
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Behcet’s Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management

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