Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asia...

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Autores principales: Tom Parks, Mariana M. Mirabel, Joseph Kado, Kathryn Auckland, Jaroslaw Nowak, Anna Rautanen, Alexander J. Mentzer, Eloi Marijon, Xavier Jouven, Mai Ling Perman, Tuliana Cua, John K. Kauwe, John B. Allen, Henry Taylor, Kathryn J. Robson, Charlotte M. Deane, Andrew C. Steer, Adrian V. S. Hill, Pacific Islands Rheumatic Heart Disease Genetics Network
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/f1a3562bc39247d39047f5629a43276b
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Sumario:Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asians.

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