Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans

In the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is pro...

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Autores principales:	Raphaela Geßele, Jacob Halatek, Laeschkir Würthner, Erwin Frey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1a4a0ddcb864ea5b149df7b466f4af8
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spelling	oai:doaj.org-article:f1a4a0ddcb864ea5b149df7b466f4af82021-12-02T16:49:15ZGeometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans10.1038/s41467-020-14317-w2041-1723https://doaj.org/article/f1a4a0ddcb864ea5b149df7b466f4af82020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14317-whttps://doaj.org/toc/2041-1723In the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is promoted by cytosolic dephosphorylation at onset and its steady state determined by minimising the length of the aPAR-pPAR interface.Raphaela GeßeleJacob HalatekLaeschkir WürthnerErwin FreyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphaela Geßele Jacob Halatek Laeschkir Würthner Erwin Frey Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
description	In the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is promoted by cytosolic dephosphorylation at onset and its steady state determined by minimising the length of the aPAR-pPAR interface.
format	article
author	Raphaela Geßele Jacob Halatek Laeschkir Würthner Erwin Frey
author_facet	Raphaela Geßele Jacob Halatek Laeschkir Würthner Erwin Frey
author_sort	Raphaela Geßele
title	Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_short	Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_full	Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_fullStr	Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_full_unstemmed	Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_sort	geometric cues stabilise long-axis polarisation of par protein patterns in c. elegans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f1a4a0ddcb864ea5b149df7b466f4af8
work_keys_str_mv	AT raphaelageßele geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans AT jacobhalatek geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans AT laeschkirwurthner geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans AT erwinfrey geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans
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Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans

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