Faecal Diagnostic Biomarkers for Colorectal Cancer

Background: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. Cancer progression, including invasion and metastasis, is a major cause of death among CRC patients. Current methods for CRC screening commonly consist of a combination of faecal immunochemical test (FIT) for sto...

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Autores principales:	Andrea Cruz, Carla M. Carvalho, Alexandra Cunha, Anais Crespo, Águeda Iglesias, Laura García-Nimo, Paulo P. Freitas, Joaquín Cubiella
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer advanced adenoma diagnosis biomarkers faecal haemoglobin M2-PK Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f1a4b2170cee495791fe9393265f9ea5
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id	oai:doaj.org-article:f1a4b2170cee495791fe9393265f9ea5
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spelling	oai:doaj.org-article:f1a4b2170cee495791fe9393265f9ea52021-11-11T15:35:27ZFaecal Diagnostic Biomarkers for Colorectal Cancer10.3390/cancers132155682072-6694https://doaj.org/article/f1a4b2170cee495791fe9393265f9ea52021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5568https://doaj.org/toc/2072-6694Background: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. Cancer progression, including invasion and metastasis, is a major cause of death among CRC patients. Current methods for CRC screening commonly consist of a combination of faecal immunochemical test (FIT) for stool occult blood detection and invasive procedures such as colonoscopy. Considering the slow progression of CRC, and that symptoms usually emerge at advanced stages, its early diagnostic can limit cancer’s spread and provide a successful treatment. Biomarkers have a high potential for the diagnosis of CRC in either blood or stool samples. Methods: In this study, we analysed the diagnostic value of six different biomarkers in stool samples of patients with CRC, advanced adenomas, other lesions and healthy individuals. We have also assessed the overall performance of the combination of these biomarkers for CRC detection. Results: The results indicate that haemoglobin (Hb) and M2-pyruvate kinase (M2-PK) levels were increased in CRC patients in comparison to the controls. Conversely, the concentrations of matrix metalloproteinase (MMP)-2, MMP-9, and tumour necrosis factor-alpha (TNF-α) were not significantly different between the tested groups. Conclusion: The combination of FIT-Hb with the M2-PK levels increased the specificity or sensitivity for CRC detection and thus present potential as faecal diagnostic biomarkers for CRC.Andrea CruzCarla M. CarvalhoAlexandra CunhaAnais CrespoÁgueda IglesiasLaura García-NimoPaulo P. FreitasJoaquín CubiellaMDPI AGarticlecolorectal canceradvanced adenomadiagnosisbiomarkersfaecal haemoglobinM2-PKNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5568, p 5568 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer advanced adenoma diagnosis biomarkers faecal haemoglobin M2-PK Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colorectal cancer advanced adenoma diagnosis biomarkers faecal haemoglobin M2-PK Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Andrea Cruz Carla M. Carvalho Alexandra Cunha Anais Crespo Águeda Iglesias Laura García-Nimo Paulo P. Freitas Joaquín Cubiella Faecal Diagnostic Biomarkers for Colorectal Cancer
description	Background: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. Cancer progression, including invasion and metastasis, is a major cause of death among CRC patients. Current methods for CRC screening commonly consist of a combination of faecal immunochemical test (FIT) for stool occult blood detection and invasive procedures such as colonoscopy. Considering the slow progression of CRC, and that symptoms usually emerge at advanced stages, its early diagnostic can limit cancer’s spread and provide a successful treatment. Biomarkers have a high potential for the diagnosis of CRC in either blood or stool samples. Methods: In this study, we analysed the diagnostic value of six different biomarkers in stool samples of patients with CRC, advanced adenomas, other lesions and healthy individuals. We have also assessed the overall performance of the combination of these biomarkers for CRC detection. Results: The results indicate that haemoglobin (Hb) and M2-pyruvate kinase (M2-PK) levels were increased in CRC patients in comparison to the controls. Conversely, the concentrations of matrix metalloproteinase (MMP)-2, MMP-9, and tumour necrosis factor-alpha (TNF-α) were not significantly different between the tested groups. Conclusion: The combination of FIT-Hb with the M2-PK levels increased the specificity or sensitivity for CRC detection and thus present potential as faecal diagnostic biomarkers for CRC.
format	article
author	Andrea Cruz Carla M. Carvalho Alexandra Cunha Anais Crespo Águeda Iglesias Laura García-Nimo Paulo P. Freitas Joaquín Cubiella
author_facet	Andrea Cruz Carla M. Carvalho Alexandra Cunha Anais Crespo Águeda Iglesias Laura García-Nimo Paulo P. Freitas Joaquín Cubiella
author_sort	Andrea Cruz
title	Faecal Diagnostic Biomarkers for Colorectal Cancer
title_short	Faecal Diagnostic Biomarkers for Colorectal Cancer
title_full	Faecal Diagnostic Biomarkers for Colorectal Cancer
title_fullStr	Faecal Diagnostic Biomarkers for Colorectal Cancer
title_full_unstemmed	Faecal Diagnostic Biomarkers for Colorectal Cancer
title_sort	faecal diagnostic biomarkers for colorectal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1a4b2170cee495791fe9393265f9ea5
work_keys_str_mv	AT andreacruz faecaldiagnosticbiomarkersforcolorectalcancer AT carlamcarvalho faecaldiagnosticbiomarkersforcolorectalcancer AT alexandracunha faecaldiagnosticbiomarkersforcolorectalcancer AT anaiscrespo faecaldiagnosticbiomarkersforcolorectalcancer AT aguedaiglesias faecaldiagnosticbiomarkersforcolorectalcancer AT lauragarcianimo faecaldiagnosticbiomarkersforcolorectalcancer AT paulopfreitas faecaldiagnosticbiomarkersforcolorectalcancer AT joaquincubiella faecaldiagnosticbiomarkersforcolorectalcancer
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Faecal Diagnostic Biomarkers for Colorectal Cancer

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