Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, which form condensates at low...

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Autores principales:	Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c
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spelling	oai:doaj.org-article:f1a7c13511ed46d3b7d48b9f4017a81c2021-12-02T12:11:27ZReentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions10.1038/s41467-021-21181-92041-1723https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21181-9https://doaj.org/toc/2041-1723Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, which form condensates at low salt concentrations, can reenter a phase-separated regime at high salt concentrations.Georg KrainerTimothy J. WelshJerelle A. JosephJorge R. EspinosaSina WittmannElla de CsilléryAkshay SridharZenon ToprakciogluGiedre GudiškytėMagdalena A. CzekalskaWilliam E. ArterJordina Guillén-BoixetTitus M. FranzmannSeema QamarPeter St George-HyslopAnthony A. HymanRosana Collepardo-GuevaraSimon AlbertiTuomas P. J. KnowlesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Georg Krainer Timothy J. Welsh Jerelle A. Joseph Jorge R. Espinosa Sina Wittmann Ella de Csilléry Akshay Sridhar Zenon Toprakcioglu Giedre Gudiškytė Magdalena A. Czekalska William E. Arter Jordina Guillén-Boixet Titus M. Franzmann Seema Qamar Peter St George-Hyslop Anthony A. Hyman Rosana Collepardo-Guevara Simon Alberti Tuomas P. J. Knowles Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
description	Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, which form condensates at low salt concentrations, can reenter a phase-separated regime at high salt concentrations.
format	article
author	Georg Krainer Timothy J. Welsh Jerelle A. Joseph Jorge R. Espinosa Sina Wittmann Ella de Csilléry Akshay Sridhar Zenon Toprakcioglu Giedre Gudiškytė Magdalena A. Czekalska William E. Arter Jordina Guillén-Boixet Titus M. Franzmann Seema Qamar Peter St George-Hyslop Anthony A. Hyman Rosana Collepardo-Guevara Simon Alberti Tuomas P. J. Knowles
author_facet	Georg Krainer Timothy J. Welsh Jerelle A. Joseph Jorge R. Espinosa Sina Wittmann Ella de Csilléry Akshay Sridhar Zenon Toprakcioglu Giedre Gudiškytė Magdalena A. Czekalska William E. Arter Jordina Guillén-Boixet Titus M. Franzmann Seema Qamar Peter St George-Hyslop Anthony A. Hyman Rosana Collepardo-Guevara Simon Alberti Tuomas P. J. Knowles
author_sort	Georg Krainer
title	Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
title_short	Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
title_full	Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
title_fullStr	Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
title_full_unstemmed	Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
title_sort	reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c
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Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

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