Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles

Herein, we report a simple and ecofriendly synthesis of ZnO nanoparticles (ZnO NPs) employing Digera muricata along with bioassay studies of synthesized NPs. The ZnO NPs obtained were indicated by a colour change from yellow to almost faint yellow giving whitish tinge and supported by the appearance...

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Autores principales:	Ashraf Naheed, Sumrra Sajjad H., Assiri Mohammed A., Usman Muhammad, Hussain Riaz, Aziz Farooq, Hussain Ajaz, Ghaffari Muhammad Abuzar, Qaisar Muhammad Naeem, Imran Muhammad, Irfan Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	digera muricata (l.) mart. bionanoparticles zno nanoparticles antimicrobial activity lipoxygenase and α-glucosidase inhibition Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f1a82f2a47e74863982b791c1e9c20fe
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spelling	oai:doaj.org-article:f1a82f2a47e74863982b791c1e9c20fe2021-12-05T14:10:50ZDigera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles2191-955010.1515/gps-2021-0044https://doaj.org/article/f1a82f2a47e74863982b791c1e9c20fe2021-08-01T00:00:00Zhttps://doi.org/10.1515/gps-2021-0044https://doaj.org/toc/2191-9550Herein, we report a simple and ecofriendly synthesis of ZnO nanoparticles (ZnO NPs) employing Digera muricata along with bioassay studies of synthesized NPs. The ZnO NPs obtained were indicated by a colour change from yellow to almost faint yellow giving whitish tinge and supported by the appearance of UV-Vis band at 373 nm and were characterized by using Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray (EDX), and scanning electron microscopy (SEM). The FT-IR spectrum confirmed the presence of biomolecules fabricated on ZnO NPs as indicated by the absorption bands at 1,378 for C–O cm−1, and ZnO NPs were also evident from the absorption bands at 440 and 670 cm−1, the former being the result of symmetric vibration of hexagonal ZnO and the latter belonged to a very weak vibration of ZnO. Its surface morphology was confirmed by SEM, and the zinc and oxygen bonds were confirmed by EDX analysis giving sharp signals for Zn and oxygen with At% of 17.58 and 30.49, respectively. The antimicrobial activity of ZnO nanoparticles was determined by the agar well diffusion method against pathogenic bacterial and fungal strains using imipenem and miconazole as standards. The results reflected that ZnO NPs enhanced the activity of plant extracts against all employed algal (E. coli, S. faecalis, P. aeruginosa, K. pneumonia, S. aureus, and B. subtilis) and fungal (T. mentogrophytes, E. floccosum, A. niger, M. canis, and F. culmorum) strains. The antibacterial and antifungal activities of extracts were enhanced by the formation of ZnO NPs. The results indicated that Digera muricata extract contains effective reducing agents for green synthesis of Digera muricata fabricated ZnO NPs, which are more potent antimicrobial than the plant extract and showed almost similar inhibition against lipoxygenase, i.e., the IC50 value of 83.82 ± 1.15, comparable to the standard.Ashraf NaheedSumrra Sajjad H.Assiri Mohammed A.Usman MuhammadHussain RiazAziz FarooqHussain AjazGhaffari Muhammad AbuzarQaisar Muhammad NaeemImran MuhammadIrfan AhmadDe Gruyterarticledigera muricata (l.) mart.bionanoparticleszno nanoparticlesantimicrobial activitylipoxygenase and α-glucosidase inhibitionChemistryQD1-999ENGreen Processing and Synthesis, Vol 10, Iss 1, Pp 476-484 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	digera muricata (l.) mart. bionanoparticles zno nanoparticles antimicrobial activity lipoxygenase and α-glucosidase inhibition Chemistry QD1-999
spellingShingle	digera muricata (l.) mart. bionanoparticles zno nanoparticles antimicrobial activity lipoxygenase and α-glucosidase inhibition Chemistry QD1-999 Ashraf Naheed Sumrra Sajjad H. Assiri Mohammed A. Usman Muhammad Hussain Riaz Aziz Farooq Hussain Ajaz Ghaffari Muhammad Abuzar Qaisar Muhammad Naeem Imran Muhammad Irfan Ahmad Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
description	Herein, we report a simple and ecofriendly synthesis of ZnO nanoparticles (ZnO NPs) employing Digera muricata along with bioassay studies of synthesized NPs. The ZnO NPs obtained were indicated by a colour change from yellow to almost faint yellow giving whitish tinge and supported by the appearance of UV-Vis band at 373 nm and were characterized by using Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray (EDX), and scanning electron microscopy (SEM). The FT-IR spectrum confirmed the presence of biomolecules fabricated on ZnO NPs as indicated by the absorption bands at 1,378 for C–O cm−1, and ZnO NPs were also evident from the absorption bands at 440 and 670 cm−1, the former being the result of symmetric vibration of hexagonal ZnO and the latter belonged to a very weak vibration of ZnO. Its surface morphology was confirmed by SEM, and the zinc and oxygen bonds were confirmed by EDX analysis giving sharp signals for Zn and oxygen with At% of 17.58 and 30.49, respectively. The antimicrobial activity of ZnO nanoparticles was determined by the agar well diffusion method against pathogenic bacterial and fungal strains using imipenem and miconazole as standards. The results reflected that ZnO NPs enhanced the activity of plant extracts against all employed algal (E. coli, S. faecalis, P. aeruginosa, K. pneumonia, S. aureus, and B. subtilis) and fungal (T. mentogrophytes, E. floccosum, A. niger, M. canis, and F. culmorum) strains. The antibacterial and antifungal activities of extracts were enhanced by the formation of ZnO NPs. The results indicated that Digera muricata extract contains effective reducing agents for green synthesis of Digera muricata fabricated ZnO NPs, which are more potent antimicrobial than the plant extract and showed almost similar inhibition against lipoxygenase, i.e., the IC50 value of 83.82 ± 1.15, comparable to the standard.
format	article
author	Ashraf Naheed Sumrra Sajjad H. Assiri Mohammed A. Usman Muhammad Hussain Riaz Aziz Farooq Hussain Ajaz Ghaffari Muhammad Abuzar Qaisar Muhammad Naeem Imran Muhammad Irfan Ahmad
author_facet	Ashraf Naheed Sumrra Sajjad H. Assiri Mohammed A. Usman Muhammad Hussain Riaz Aziz Farooq Hussain Ajaz Ghaffari Muhammad Abuzar Qaisar Muhammad Naeem Imran Muhammad Irfan Ahmad
author_sort	Ashraf Naheed
title	Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
title_short	Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
title_full	Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
title_fullStr	Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
title_full_unstemmed	Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
title_sort	digera muricata (l.) mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/f1a82f2a47e74863982b791c1e9c20fe
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Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles

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