Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.

Calcium silicate (CaSiO3, CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectro...

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Autores principales:	Mehdi Mehrali, Ehsan Moghaddam, Seyed Farid Seyed Shirazi, Saeid Baradaran, Mohammad Mehrali, Sara Tahan Latibari, Hendrik Simon Cornelis Metselaar, Nahrizul Adib Kadri, Keivan Zandi, Noor Azuan Abu Osman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1a8be865a6a42449069e6f8be2d6d51
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spelling	oai:doaj.org-article:f1a8be865a6a42449069e6f8be2d6d512021-11-25T06:00:19ZMechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.1932-620310.1371/journal.pone.0106802https://doaj.org/article/f1a8be865a6a42449069e6f8be2d6d512014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0106802https://doaj.org/toc/1932-6203Calcium silicate (CaSiO3, CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectroscopy and scanning electron microscopy showed that GNP survived the harsh processing conditions of the selected HIP processing parameters. The uniform distribution of 1 wt.% GNP in the CS matrix, high densification and fine CS grain size help to improve the fracture toughness by ∼130%, hardness by ∼30% and brittleness index by ∼40% as compared to the CS matrix without GNP. The toughening mechanisms, such as crack bridging, pull-out, branching and deflection induced by GNP are observed and discussed. The GNP/CS composites exhibit good apatite-forming ability in the simulated body fluid (SBF). Our results indicate that the addition of GNP decreased pH value in SBF. Effect of addition of GNP on early adhesion and proliferation of human osteoblast cells (hFOB) was measured in vitro. The GNP/CS composites showed good biocompatibility and promoted cell viability and cell proliferation. The results indicated that the cell viability and proliferation are affected by time and concentration of GNP in the CS matrix.Mehdi MehraliEhsan MoghaddamSeyed Farid Seyed ShiraziSaeid BaradaranMohammad MehraliSara Tahan LatibariHendrik Simon Cornelis MetselaarNahrizul Adib KadriKeivan ZandiNoor Azuan Abu OsmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106802 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mehdi Mehrali Ehsan Moghaddam Seyed Farid Seyed Shirazi Saeid Baradaran Mohammad Mehrali Sara Tahan Latibari Hendrik Simon Cornelis Metselaar Nahrizul Adib Kadri Keivan Zandi Noor Azuan Abu Osman Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
description	Calcium silicate (CaSiO3, CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectroscopy and scanning electron microscopy showed that GNP survived the harsh processing conditions of the selected HIP processing parameters. The uniform distribution of 1 wt.% GNP in the CS matrix, high densification and fine CS grain size help to improve the fracture toughness by ∼130%, hardness by ∼30% and brittleness index by ∼40% as compared to the CS matrix without GNP. The toughening mechanisms, such as crack bridging, pull-out, branching and deflection induced by GNP are observed and discussed. The GNP/CS composites exhibit good apatite-forming ability in the simulated body fluid (SBF). Our results indicate that the addition of GNP decreased pH value in SBF. Effect of addition of GNP on early adhesion and proliferation of human osteoblast cells (hFOB) was measured in vitro. The GNP/CS composites showed good biocompatibility and promoted cell viability and cell proliferation. The results indicated that the cell viability and proliferation are affected by time and concentration of GNP in the CS matrix.
format	article
author	Mehdi Mehrali Ehsan Moghaddam Seyed Farid Seyed Shirazi Saeid Baradaran Mohammad Mehrali Sara Tahan Latibari Hendrik Simon Cornelis Metselaar Nahrizul Adib Kadri Keivan Zandi Noor Azuan Abu Osman
author_facet	Mehdi Mehrali Ehsan Moghaddam Seyed Farid Seyed Shirazi Saeid Baradaran Mohammad Mehrali Sara Tahan Latibari Hendrik Simon Cornelis Metselaar Nahrizul Adib Kadri Keivan Zandi Noor Azuan Abu Osman
author_sort	Mehdi Mehrali
title	Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
title_short	Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
title_full	Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
title_fullStr	Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
title_full_unstemmed	Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
title_sort	mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f1a8be865a6a42449069e6f8be2d6d51
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_version_	1718414316048220160

Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite.

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