E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities

Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi). Several NTPDase isoforms have been described in different cells, from pathogenic organisms to an...

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Autores principales:	Lisvane Paes-Vieira, André Luiz Gomes-Vieira, José Roberto Meyer-Fernandes
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Ecto-nucleotidases E-NTPDases purinergic signaling parasite infection antiparasitic drugs Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f1a9010f933743be9cd394b44cf3cddd
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id	oai:doaj.org-article:f1a9010f933743be9cd394b44cf3cddd
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spelling	oai:doaj.org-article:f1a9010f933743be9cd394b44cf3cddd2021-11-09T05:43:25ZE-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities2235-298810.3389/fcimb.2021.769922https://doaj.org/article/f1a9010f933743be9cd394b44cf3cddd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.769922/fullhttps://doaj.org/toc/2235-2988Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi). Several NTPDase isoforms have been described in different cells, from pathogenic organisms to animals and plants. Biochemical characterization of nucleotidases/NTPDases has revealed the existence of isoforms with different specificities regarding divalent cations (such as calcium and magnesium) and substrates. In mammals, NTPDases have been implicated in the regulation of thrombosis and inflammation. In parasites, such as Trichomonas vaginalis, Trypanosoma spp., Leishmania spp., Schistosoma spp. and Toxoplasma gondii, NTPDases were found on the surface of the cell, and important processes like growth, infectivity, and virulence seem to depend on their activity. For instance, experimental evidence has indicated that parasite NTPDases can regulate the levels of ATP and Adenosine (Ado) of the host cell, leading to the modulation of the host immune response. In this work, we provide a comprehensive review showing the involvement of the nucleotidases/NTPDases in parasites infectivity and virulence, and how inhibition of NTPDases contributes to parasite clearance and the development of new antiparasitic drugs.Lisvane Paes-VieiraAndré Luiz Gomes-VieiraJosé Roberto Meyer-FernandesJosé Roberto Meyer-FernandesFrontiers Media S.A.articleEcto-nucleotidasesE-NTPDasespurinergic signalingparasite infectionantiparasitic drugsMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ecto-nucleotidases E-NTPDases purinergic signaling parasite infection antiparasitic drugs Microbiology QR1-502
spellingShingle	Ecto-nucleotidases E-NTPDases purinergic signaling parasite infection antiparasitic drugs Microbiology QR1-502 Lisvane Paes-Vieira André Luiz Gomes-Vieira José Roberto Meyer-Fernandes José Roberto Meyer-Fernandes E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
description	Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi). Several NTPDase isoforms have been described in different cells, from pathogenic organisms to animals and plants. Biochemical characterization of nucleotidases/NTPDases has revealed the existence of isoforms with different specificities regarding divalent cations (such as calcium and magnesium) and substrates. In mammals, NTPDases have been implicated in the regulation of thrombosis and inflammation. In parasites, such as Trichomonas vaginalis, Trypanosoma spp., Leishmania spp., Schistosoma spp. and Toxoplasma gondii, NTPDases were found on the surface of the cell, and important processes like growth, infectivity, and virulence seem to depend on their activity. For instance, experimental evidence has indicated that parasite NTPDases can regulate the levels of ATP and Adenosine (Ado) of the host cell, leading to the modulation of the host immune response. In this work, we provide a comprehensive review showing the involvement of the nucleotidases/NTPDases in parasites infectivity and virulence, and how inhibition of NTPDases contributes to parasite clearance and the development of new antiparasitic drugs.
format	article
author	Lisvane Paes-Vieira André Luiz Gomes-Vieira José Roberto Meyer-Fernandes José Roberto Meyer-Fernandes
author_facet	Lisvane Paes-Vieira André Luiz Gomes-Vieira José Roberto Meyer-Fernandes José Roberto Meyer-Fernandes
author_sort	Lisvane Paes-Vieira
title	E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
title_short	E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
title_full	E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
title_fullStr	E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
title_full_unstemmed	E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
title_sort	e-ntpdases: possible roles on host-parasite interactions and therapeutic opportunities
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f1a9010f933743be9cd394b44cf3cddd
work_keys_str_mv	AT lisvanepaesvieira entpdasespossiblerolesonhostparasiteinteractionsandtherapeuticopportunities AT andreluizgomesvieira entpdasespossiblerolesonhostparasiteinteractionsandtherapeuticopportunities AT joserobertomeyerfernandes entpdasespossiblerolesonhostparasiteinteractionsandtherapeuticopportunities AT joserobertomeyerfernandes entpdasespossiblerolesonhostparasiteinteractionsandtherapeuticopportunities
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E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities

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