Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases

Yuko Tsunoda,1 Akiko Sasaki,2 Naomi Sakamoto,1 Kou Teraoka,1 Rie Nakagawa,1 Yoshitomo Koshida,1 Eisuke Fukuma1 1Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan; 2Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan Background: Identification...

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Autores principales:	Tsunoda Y, Sasaki A, Sakamoto N, Teraoka K, Nakagawa R, Koshida Y, Fukuma E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Breast cancer Estrogen receptor fatty acid synthase micro RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f1a948b3473e4cb2b17e98dbade4ff09
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spelling	oai:doaj.org-article:f1a948b3473e4cb2b17e98dbade4ff092021-12-02T00:20:32ZProtein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases1179-1314https://doaj.org/article/f1a948b3473e4cb2b17e98dbade4ff092018-11-01T00:00:00Zhttps://www.dovepress.com/protein-expression-profile-and-microrna-expression-signature-in-estrog-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Yuko Tsunoda,1 Akiko Sasaki,2 Naomi Sakamoto,1 Kou Teraoka,1 Rie Nakagawa,1 Yoshitomo Koshida,1 Eisuke Fukuma1 1Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan; 2Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan Background: Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, the proteins associated with ER status were reported using liquid chromatography and tandem mass spectrometry, and microRNA (miRNA) profiling of breast cancer subtype was demonstrated using real-time-PCR. Methods: We present herein two cases with differential protein expression and miRNA profiling in ER-positive and -negative breast cancer. Results: Proteins associated with fatty acid metabolism were uniquely detected in ER-positive breast cancer. The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. Conclusion: These cases suggest that fatty acid synthase (FAS) and FAS-related miRNAs are important in ER-positive breast cancer. Keywords: breast cancer, estrogen receptor, fatty acid synthase, microRNA Tsunoda YSasaki ASakamoto NTeraoka KNakagawa RKoshida YFukuma EDove Medical PressarticleBreast cancerEstrogen receptorfatty acid synthasemicro RNANeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 10, Pp 195-199 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer Estrogen receptor fatty acid synthase micro RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer Estrogen receptor fatty acid synthase micro RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tsunoda Y Sasaki A Sakamoto N Teraoka K Nakagawa R Koshida Y Fukuma E Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
description	Yuko Tsunoda,1 Akiko Sasaki,2 Naomi Sakamoto,1 Kou Teraoka,1 Rie Nakagawa,1 Yoshitomo Koshida,1 Eisuke Fukuma1 1Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan; 2Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan Background: Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, the proteins associated with ER status were reported using liquid chromatography and tandem mass spectrometry, and microRNA (miRNA) profiling of breast cancer subtype was demonstrated using real-time-PCR. Methods: We present herein two cases with differential protein expression and miRNA profiling in ER-positive and -negative breast cancer. Results: Proteins associated with fatty acid metabolism were uniquely detected in ER-positive breast cancer. The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. Conclusion: These cases suggest that fatty acid synthase (FAS) and FAS-related miRNAs are important in ER-positive breast cancer. Keywords: breast cancer, estrogen receptor, fatty acid synthase, microRNA
format	article
author	Tsunoda Y Sasaki A Sakamoto N Teraoka K Nakagawa R Koshida Y Fukuma E
author_facet	Tsunoda Y Sasaki A Sakamoto N Teraoka K Nakagawa R Koshida Y Fukuma E
author_sort	Tsunoda Y
title	Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
title_short	Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
title_full	Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
title_fullStr	Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
title_full_unstemmed	Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
title_sort	protein expression profile and microrna expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f1a948b3473e4cb2b17e98dbade4ff09
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Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases

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