Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.
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Nature Portfolio
2019
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oai:doaj.org-article:f1ab52ee34d04a798436204eedf97a8a2021-12-02T15:35:15ZNeuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma10.1038/s41467-019-10307-92041-1723https://doaj.org/article/f1ab52ee34d04a798436204eedf97a8a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10307-9https://doaj.org/toc/2041-1723BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.Pratiti BandopadhayayFederica PiccioniRyan O’RourkePatricia HoElizabeth M. GonzalezGraham BuchanKenin QianGabrielle GionetEmily GirardMargo CoxonMatthew G. ReesLisa BrenanFrank DuboisOfer ShapiraNoah F. GreenwaldMelanie PagesAmanda Balboni IniguezBrenton R. PaolellaAlice MengClaire SinaiGiovanni RotiNeekesh V. DhariaAmanda CreechBenjamin TanenbaumPrasidda KhadkaAdam TracyHong L. TivAndrew L. HongShannon CoyRumana RashidJia-Ren LinGlenn S. CowleyFred C. LamAmy GoodaleYenarae LeeKathleen SchoolcraftFrancisca VazquezWilliam C. HahnAviad TsherniakJames E. BradnerMichael B. YaffeTill MildeStefan M. PfisterJun QiMonica SchenoneSteven A. CarrKeith L. LigonMark W. KieranSandro SantagataJames M. OlsonPrafulla C. GokhaleJacob D. JaffeDavid E. RootKimberly StegmaierCory M. JohannessenRameen BeroukhimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Pratiti Bandopadhayay Federica Piccioni Ryan O’Rourke Patricia Ho Elizabeth M. Gonzalez Graham Buchan Kenin Qian Gabrielle Gionet Emily Girard Margo Coxon Matthew G. Rees Lisa Brenan Frank Dubois Ofer Shapira Noah F. Greenwald Melanie Pages Amanda Balboni Iniguez Brenton R. Paolella Alice Meng Claire Sinai Giovanni Roti Neekesh V. Dharia Amanda Creech Benjamin Tanenbaum Prasidda Khadka Adam Tracy Hong L. Tiv Andrew L. Hong Shannon Coy Rumana Rashid Jia-Ren Lin Glenn S. Cowley Fred C. Lam Amy Goodale Yenarae Lee Kathleen Schoolcraft Francisca Vazquez William C. Hahn Aviad Tsherniak James E. Bradner Michael B. Yaffe Till Milde Stefan M. Pfister Jun Qi Monica Schenone Steven A. Carr Keith L. Ligon Mark W. Kieran Sandro Santagata James M. Olson Prafulla C. Gokhale Jacob D. Jaffe David E. Root Kimberly Stegmaier Cory M. Johannessen Rameen Beroukhim Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| description |
BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors. |
| format |
article |
| author |
Pratiti Bandopadhayay Federica Piccioni Ryan O’Rourke Patricia Ho Elizabeth M. Gonzalez Graham Buchan Kenin Qian Gabrielle Gionet Emily Girard Margo Coxon Matthew G. Rees Lisa Brenan Frank Dubois Ofer Shapira Noah F. Greenwald Melanie Pages Amanda Balboni Iniguez Brenton R. Paolella Alice Meng Claire Sinai Giovanni Roti Neekesh V. Dharia Amanda Creech Benjamin Tanenbaum Prasidda Khadka Adam Tracy Hong L. Tiv Andrew L. Hong Shannon Coy Rumana Rashid Jia-Ren Lin Glenn S. Cowley Fred C. Lam Amy Goodale Yenarae Lee Kathleen Schoolcraft Francisca Vazquez William C. Hahn Aviad Tsherniak James E. Bradner Michael B. Yaffe Till Milde Stefan M. Pfister Jun Qi Monica Schenone Steven A. Carr Keith L. Ligon Mark W. Kieran Sandro Santagata James M. Olson Prafulla C. Gokhale Jacob D. Jaffe David E. Root Kimberly Stegmaier Cory M. Johannessen Rameen Beroukhim |
| author_facet |
Pratiti Bandopadhayay Federica Piccioni Ryan O’Rourke Patricia Ho Elizabeth M. Gonzalez Graham Buchan Kenin Qian Gabrielle Gionet Emily Girard Margo Coxon Matthew G. Rees Lisa Brenan Frank Dubois Ofer Shapira Noah F. Greenwald Melanie Pages Amanda Balboni Iniguez Brenton R. Paolella Alice Meng Claire Sinai Giovanni Roti Neekesh V. Dharia Amanda Creech Benjamin Tanenbaum Prasidda Khadka Adam Tracy Hong L. Tiv Andrew L. Hong Shannon Coy Rumana Rashid Jia-Ren Lin Glenn S. Cowley Fred C. Lam Amy Goodale Yenarae Lee Kathleen Schoolcraft Francisca Vazquez William C. Hahn Aviad Tsherniak James E. Bradner Michael B. Yaffe Till Milde Stefan M. Pfister Jun Qi Monica Schenone Steven A. Carr Keith L. Ligon Mark W. Kieran Sandro Santagata James M. Olson Prafulla C. Gokhale Jacob D. Jaffe David E. Root Kimberly Stegmaier Cory M. Johannessen Rameen Beroukhim |
| author_sort |
Pratiti Bandopadhayay |
| title |
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| title_short |
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| title_full |
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| title_fullStr |
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| title_full_unstemmed |
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma |
| title_sort |
neuronal differentiation and cell-cycle programs mediate response to bet-bromodomain inhibition in myc-driven medulloblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/f1ab52ee34d04a798436204eedf97a8a |
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