The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) or Parkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has been a permanent challenge to science. New tools were developed over the past two decades and were immediately incorporated into r...

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Autores principales:	Thiago M. C. Pereira, Larissa Z. Côco, Alyne M. M. Ton, Silvana S. Meyrelles, Manuel Campos-Toimil, Bianca P. Campagnaro, Elisardo C. Vasquez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress inflammation neurodegenerative diseases kefir chronic focal encephalitis angiotensin II Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f1afbed199e54f1a8ad543881896922e
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spelling	oai:doaj.org-article:f1afbed199e54f1a8ad543881896922e2021-11-25T16:29:46ZThe Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases10.3390/antiox101118452076-3921https://doaj.org/article/f1afbed199e54f1a8ad543881896922e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1845https://doaj.org/toc/2076-3921The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) or Parkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has been a permanent challenge to science. New tools were developed over the past two decades and were immediately incorporated into routines in many laboratories, but the most valuable scientific contribution was the “waking up” of the gut microbiota. Disturbances in the gut microbiota, such as an imbalance in the beneficial/pathogenic effects and a decrease in diversity, can result in the passage of undesired chemicals and cells to the systemic circulation. Recently, the potential effect of probiotics on restoring/preserving the microbiota was also evaluated regarding important metabolite and vitamin production, pathogen exclusion, immune system maturation, and intestinal mucosal barrier integrity. Therefore, the focus of the present review is to discuss the available data and conclude what has been accomplished over the past two decades. This perspective fosters program development of the next steps that are necessary to obtain confirmation through clinical trials on the magnitude of the effects of kefir in large samples.Thiago M. C. PereiraLarissa Z. CôcoAlyne M. M. TonSilvana S. MeyrellesManuel Campos-ToimilBianca P. CampagnaroElisardo C. VasquezMDPI AGarticleoxidative stressinflammationneurodegenerative diseaseskefirchronic focal encephalitisangiotensin IITherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1845, p 1845 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress inflammation neurodegenerative diseases kefir chronic focal encephalitis angiotensin II Therapeutics. Pharmacology RM1-950
spellingShingle	oxidative stress inflammation neurodegenerative diseases kefir chronic focal encephalitis angiotensin II Therapeutics. Pharmacology RM1-950 Thiago M. C. Pereira Larissa Z. Côco Alyne M. M. Ton Silvana S. Meyrelles Manuel Campos-Toimil Bianca P. Campagnaro Elisardo C. Vasquez The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
description	The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) or Parkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has been a permanent challenge to science. New tools were developed over the past two decades and were immediately incorporated into routines in many laboratories, but the most valuable scientific contribution was the “waking up” of the gut microbiota. Disturbances in the gut microbiota, such as an imbalance in the beneficial/pathogenic effects and a decrease in diversity, can result in the passage of undesired chemicals and cells to the systemic circulation. Recently, the potential effect of probiotics on restoring/preserving the microbiota was also evaluated regarding important metabolite and vitamin production, pathogen exclusion, immune system maturation, and intestinal mucosal barrier integrity. Therefore, the focus of the present review is to discuss the available data and conclude what has been accomplished over the past two decades. This perspective fosters program development of the next steps that are necessary to obtain confirmation through clinical trials on the magnitude of the effects of kefir in large samples.
format	article
author	Thiago M. C. Pereira Larissa Z. Côco Alyne M. M. Ton Silvana S. Meyrelles Manuel Campos-Toimil Bianca P. Campagnaro Elisardo C. Vasquez
author_facet	Thiago M. C. Pereira Larissa Z. Côco Alyne M. M. Ton Silvana S. Meyrelles Manuel Campos-Toimil Bianca P. Campagnaro Elisardo C. Vasquez
author_sort	Thiago M. C. Pereira
title	The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
title_short	The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
title_full	The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
title_fullStr	The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
title_full_unstemmed	The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
title_sort	emerging scenario of the gut–brain axis: the therapeutic actions of the new actor kefir against neurodegenerative diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1afbed199e54f1a8ad543881896922e
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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

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