Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thiophenes in the context of a rare remote asymmetric...

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Main Authors:	Xingguang Li, Meng Duan, Peiyuan Yu, K. N. Houk, Jianwei Sun
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/f1b220f76da84e57b7b0847cd96eb28d
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spelling	oai:doaj.org-article:f1b220f76da84e57b7b0847cd96eb28d2021-12-02T19:06:33ZOrganocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides10.1038/s41467-021-25165-72041-1723https://doaj.org/article/f1b220f76da84e57b7b0847cd96eb28d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25165-7https://doaj.org/toc/2041-1723Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thiophenes in the context of a rare remote asymmetric 1,10-conjugate addition.Xingguang LiMeng DuanPeiyuan YuK. N. HoukJianwei SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xingguang Li Meng Duan Peiyuan Yu K. N. Houk Jianwei Sun Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
description	Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thiophenes in the context of a rare remote asymmetric 1,10-conjugate addition.
format	article
author	Xingguang Li Meng Duan Peiyuan Yu K. N. Houk Jianwei Sun
author_facet	Xingguang Li Meng Duan Peiyuan Yu K. N. Houk Jianwei Sun
author_sort	Xingguang Li
title	Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
title_short	Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
title_full	Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
title_fullStr	Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
title_full_unstemmed	Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
title_sort	organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f1b220f76da84e57b7b0847cd96eb28d
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Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

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