Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into its catalytic mechanism and a basis for GnT-V...

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Autores principales:	Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi, Yoshiki Yamaguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1b4c8dd92254367b426de0599de41f5
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spelling	oai:doaj.org-article:f1b4c8dd92254367b426de0599de41f52021-12-02T14:39:24ZStructure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V10.1038/s41467-018-05931-w2041-1723https://doaj.org/article/f1b4c8dd92254367b426de0599de41f52018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05931-whttps://doaj.org/toc/2041-1723The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into its catalytic mechanism and a basis for GnT-V inhibition.Masamichi NagaeYasuhiko KizukaEmiko MiharaYu KitagoShinya HanashimaYukishige ItoJunichi TakagiNaoyuki TaniguchiYoshiki YamaguchiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masamichi Nagae Yasuhiko Kizuka Emiko Mihara Yu Kitago Shinya Hanashima Yukishige Ito Junichi Takagi Naoyuki Taniguchi Yoshiki Yamaguchi Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
description	The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into its catalytic mechanism and a basis for GnT-V inhibition.
format	article
author	Masamichi Nagae Yasuhiko Kizuka Emiko Mihara Yu Kitago Shinya Hanashima Yukishige Ito Junichi Takagi Naoyuki Taniguchi Yoshiki Yamaguchi
author_facet	Masamichi Nagae Yasuhiko Kizuka Emiko Mihara Yu Kitago Shinya Hanashima Yukishige Ito Junichi Takagi Naoyuki Taniguchi Yoshiki Yamaguchi
author_sort	Masamichi Nagae
title	Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
title_short	Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
title_full	Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
title_fullStr	Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
title_full_unstemmed	Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
title_sort	structure and mechanism of cancer-associated n-acetylglucosaminyltransferase-v
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f1b4c8dd92254367b426de0599de41f5
work_keys_str_mv	AT masamichinagae structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT yasuhikokizuka structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT emikomihara structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT yukitago structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT shinyahanashima structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT yukishigeito structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT junichitakagi structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT naoyukitaniguchi structureandmechanismofcancerassociatednacetylglucosaminyltransferasev AT yoshikiyamaguchi structureandmechanismofcancerassociatednacetylglucosaminyltransferasev
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Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

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