An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity

ABSTRACT Although discovered over 50 years ago, the physiological role of enterobacterial common antigen, a surface antigen produced by all members of the Enterobacteriaceae, has been poorly understood. In the work of Mitchell et al. (mBio 9:e01321-18, 2018, https://doi.org/10.1128/mBio.01321-18), t...

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Autor principal:	Corey S. Westfall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	ECA enterobacterial common antigen Escherichia coli outer membrane Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f1b62061e86d4f0ebc123c478e684020
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spelling	oai:doaj.org-article:f1b62061e86d4f0ebc123c478e6840202021-11-15T15:58:21ZAn “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity10.1128/mBio.02162-182150-7511https://doaj.org/article/f1b62061e86d4f0ebc123c478e6840202018-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02162-18https://doaj.org/toc/2150-7511ABSTRACT Although discovered over 50 years ago, the physiological role of enterobacterial common antigen, a surface antigen produced by all members of the Enterobacteriaceae, has been poorly understood. In the work of Mitchell et al. (mBio 9:e01321-18, 2018, https://doi.org/10.1128/mBio.01321-18), the cyclized version of enterobacterial common antigen has been shown to play a role in maintaining the outer membrane permeability barrier, possibly through the inner membrane protein YhdP. This work also provides the tests needed to separate true effects from the numerous possible artifacts possible with mutations in enterobacterial common antigen synthesis.Corey S. WestfallAmerican Society for MicrobiologyarticleECAenterobacterial common antigenEscherichia coliouter membraneMicrobiologyQR1-502ENmBio, Vol 9, Iss 5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ECA enterobacterial common antigen Escherichia coli outer membrane Microbiology QR1-502
spellingShingle	ECA enterobacterial common antigen Escherichia coli outer membrane Microbiology QR1-502 Corey S. Westfall An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
description	ABSTRACT Although discovered over 50 years ago, the physiological role of enterobacterial common antigen, a surface antigen produced by all members of the Enterobacteriaceae, has been poorly understood. In the work of Mitchell et al. (mBio 9:e01321-18, 2018, https://doi.org/10.1128/mBio.01321-18), the cyclized version of enterobacterial common antigen has been shown to play a role in maintaining the outer membrane permeability barrier, possibly through the inner membrane protein YhdP. This work also provides the tests needed to separate true effects from the numerous possible artifacts possible with mutations in enterobacterial common antigen synthesis.
format	article
author	Corey S. Westfall
author_facet	Corey S. Westfall
author_sort	Corey S. Westfall
title	An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
title_short	An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
title_full	An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
title_fullStr	An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
title_full_unstemmed	An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity
title_sort	“uncommon” role for cyclic enterobacterial common antigen in maintaining outer membrane integrity
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/f1b62061e86d4f0ebc123c478e684020
work_keys_str_mv	AT coreyswestfall anuncommonroleforcyclicenterobacterialcommonantigeninmaintainingoutermembraneintegrity AT coreyswestfall uncommonroleforcyclicenterobacterialcommonantigeninmaintainingoutermembraneintegrity
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An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity

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