Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression

Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression

Cyclin E1 (CCNE1) is a regulatory subunit of Cyclin-dependent kinase 2 (CDK2) and is thought to control the transition of quiescent cells into cell cycle progression. Recently, we identified CCNE1 and CDK2 as key factors for the initiation of hepatocellular carcinoma (HCC). In the present study, we...

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Bibliographic Details
Main Authors: Roland Sonntag, Christian Penners, Marlene Kohlhepp, Ute Haas, Daniela Lambertz, Andreas Kroh, Thorsten Cramer, Fabio Ticconi, Ivan G. Costa, Frank Tacke, Nikolaus Gassler, Christian Trautwein, Christian Liedtke
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cell cycle
cancer stem cell
microenvironment
microinvasion
DNA integrity
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/f1b7e5a6281046dcb9a3bcb739e2f045
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https://doaj.org/article/f1b7e5a6281046dcb9a3bcb739e2f045

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