In vivo epidermal migration requires focal adhesion targeting of ACF7

The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal adhesion dynamics in vitro and in vivo.

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Autores principales:	Jiping Yue, Yao Zhang, Wenguang G. Liang, Xuewen Gou, Philbert Lee, Han Liu, Wanqing Lyu, Wei-Jen Tang, Shao-Yu Chen, Feng Yang, Hong Liang, Xiaoyang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1b9a1f82978443286b0a25d4146f0c2
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spelling	oai:doaj.org-article:f1b9a1f82978443286b0a25d4146f0c22021-12-02T16:57:29ZIn vivo epidermal migration requires focal adhesion targeting of ACF710.1038/ncomms116922041-1723https://doaj.org/article/f1b9a1f82978443286b0a25d4146f0c22016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11692https://doaj.org/toc/2041-1723The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal adhesion dynamics in vitro and in vivo.Jiping YueYao ZhangWenguang G. LiangXuewen GouPhilbert LeeHan LiuWanqing LyuWei-Jen TangShao-Yu ChenFeng YangHong LiangXiaoyang WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiping Yue Yao Zhang Wenguang G. Liang Xuewen Gou Philbert Lee Han Liu Wanqing Lyu Wei-Jen Tang Shao-Yu Chen Feng Yang Hong Liang Xiaoyang Wu In vivo epidermal migration requires focal adhesion targeting of ACF7
description	The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal adhesion dynamics in vitro and in vivo.
format	article
author	Jiping Yue Yao Zhang Wenguang G. Liang Xuewen Gou Philbert Lee Han Liu Wanqing Lyu Wei-Jen Tang Shao-Yu Chen Feng Yang Hong Liang Xiaoyang Wu
author_facet	Jiping Yue Yao Zhang Wenguang G. Liang Xuewen Gou Philbert Lee Han Liu Wanqing Lyu Wei-Jen Tang Shao-Yu Chen Feng Yang Hong Liang Xiaoyang Wu
author_sort	Jiping Yue
title	In vivo epidermal migration requires focal adhesion targeting of ACF7
title_short	In vivo epidermal migration requires focal adhesion targeting of ACF7
title_full	In vivo epidermal migration requires focal adhesion targeting of ACF7
title_fullStr	In vivo epidermal migration requires focal adhesion targeting of ACF7
title_full_unstemmed	In vivo epidermal migration requires focal adhesion targeting of ACF7
title_sort	in vivo epidermal migration requires focal adhesion targeting of acf7
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f1b9a1f82978443286b0a25d4146f0c2
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In vivo epidermal migration requires focal adhesion targeting of ACF7

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