Versatile cell-based assay for measuring DNA alkylation damage and its repair

Versatile cell-based assay for measuring DNA alkylation damage and its repair

Abstract DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repair pathway that removes alkylation damage from DNA...

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Autores principales: Yong Li, Peng Mao, Evelina Y. Basenko, Zachary Lewis, Michael J. Smerdon, Wioletta Czaja
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f1ba10e57c694615a5775bd8ddef661d
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