Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study

Abstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on th...

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Autores principales:	Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1ba198772ad42268f38472c56c04c1a
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spelling	oai:doaj.org-article:f1ba198772ad42268f38472c56c04c1a2021-12-02T15:05:40ZGlobal associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study10.1038/s41598-017-10104-82045-2322https://doaj.org/article/f1ba198772ad42268f38472c56c04c1a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10104-8https://doaj.org/toc/2045-2322Abstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.Hikaru TakeuchiYasuyuki TakiRui NouchiRyoichi YokoyamaYuka KotozakiSeishu NakagawaAtsushi SekiguchiKunio IizukaYuki YamamotoSugiko HanawaTsuyoshi ArakiCarlos Makoto MiyauchiTakamitsu ShinadaKohei SakakiYuko SassaTakayuki NozawaShigeyuki IkedaSusumu YokotaMagistro DanieleRyuta KawashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
description	Abstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.
format	article
author	Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima
author_facet	Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima
author_sort	Hikaru Takeuchi
title	Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
title_short	Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
title_full	Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
title_fullStr	Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
title_full_unstemmed	Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
title_sort	global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f1ba198772ad42268f38472c56c04c1a
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Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study

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