The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised

Mtl1protein is a cell wall receptor belonging to the CWI pathway. Mtl1 function is related to glucose and oxidative stress signaling. In this report, we show data demonstrating that Mtl1 plays a critical role in the detection of a descent in glucose concentration, in order to activate bulk autophagy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sandra Montella-Manuel, Nuria Pujol-Carrion, Maria Angeles de la Torre-Ruiz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy <i>Saccharomyces cerevisiae</i> Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f1c1391f4322418a8fa59d1e287b2ebc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1c1391f4322418a8fa59d1e287b2ebc
record_format	dspace
spelling	oai:doaj.org-article:f1c1391f4322418a8fa59d1e287b2ebc2021-11-25T18:05:36ZThe Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised10.3390/jof71109032309-608Xhttps://doaj.org/article/f1c1391f4322418a8fa59d1e287b2ebc2021-10-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/903https://doaj.org/toc/2309-608XMtl1protein is a cell wall receptor belonging to the CWI pathway. Mtl1 function is related to glucose and oxidative stress signaling. In this report, we show data demonstrating that Mtl1 plays a critical role in the detection of a descent in glucose concentration, in order to activate bulk autophagy machinery as a response to nutrient deprivation and to maintain cell survival in starvation conditions. Autophagy is a tightly regulated mechanism involving several signaling pathways. The data here show that in <i>Saccharomyces</i> <i>cerevisiae</i>, Mtl1 signals glucose availability to either Ras2 or Sch9 proteins converging in Atg1 phosphorylation and autophagy induction. TORC1 complex function is not involved in autophagy induction during the diauxic shift when glucose is limited. In this context, the <i>GCN2</i> gene is required to regulate autophagy activation upon amino acid starvation independent of the TORC1 complex. Mtl1 function is also involved in signaling the autophagic degradation of mitochondria during the stationary phase through both Ras2 and Sch9, in a manner dependent on either Atg33 and Atg11 proteins and independent of the Atg32 protein, the mitophagy receptor. All of the above suggest a pivotal signaling role for Mtl1 in maintaining correct cell homeostasis function in periods of glucose scarcity in budding yeast.Sandra Montella-ManuelNuria Pujol-CarrionMaria Angeles de la Torre-RuizMDPI AGarticlecell wall integrity (CWI)Mtl1autophagyglucosemitophagy<i>Saccharomyces cerevisiae</i>Biology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 903, p 903 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy <i>Saccharomyces cerevisiae</i> Biology (General) QH301-705.5
spellingShingle	cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy <i>Saccharomyces cerevisiae</i> Biology (General) QH301-705.5 Sandra Montella-Manuel Nuria Pujol-Carrion Maria Angeles de la Torre-Ruiz The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
description	Mtl1protein is a cell wall receptor belonging to the CWI pathway. Mtl1 function is related to glucose and oxidative stress signaling. In this report, we show data demonstrating that Mtl1 plays a critical role in the detection of a descent in glucose concentration, in order to activate bulk autophagy machinery as a response to nutrient deprivation and to maintain cell survival in starvation conditions. Autophagy is a tightly regulated mechanism involving several signaling pathways. The data here show that in <i>Saccharomyces</i> <i>cerevisiae</i>, Mtl1 signals glucose availability to either Ras2 or Sch9 proteins converging in Atg1 phosphorylation and autophagy induction. TORC1 complex function is not involved in autophagy induction during the diauxic shift when glucose is limited. In this context, the <i>GCN2</i> gene is required to regulate autophagy activation upon amino acid starvation independent of the TORC1 complex. Mtl1 function is also involved in signaling the autophagic degradation of mitochondria during the stationary phase through both Ras2 and Sch9, in a manner dependent on either Atg33 and Atg11 proteins and independent of the Atg32 protein, the mitophagy receptor. All of the above suggest a pivotal signaling role for Mtl1 in maintaining correct cell homeostasis function in periods of glucose scarcity in budding yeast.
format	article
author	Sandra Montella-Manuel Nuria Pujol-Carrion Maria Angeles de la Torre-Ruiz
author_facet	Sandra Montella-Manuel Nuria Pujol-Carrion Maria Angeles de la Torre-Ruiz
author_sort	Sandra Montella-Manuel
title	The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
title_short	The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
title_full	The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
title_fullStr	The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
title_full_unstemmed	The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
title_sort	cell wall integrity receptor mtl1 contributes to articulate autophagic responses when glucose availability is compromised
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1c1391f4322418a8fa59d1e287b2ebc
work_keys_str_mv	AT sandramontellamanuel thecellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised AT nuriapujolcarrion thecellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised AT mariaangelesdelatorreruiz thecellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised AT sandramontellamanuel cellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised AT nuriapujolcarrion cellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised AT mariaangelesdelatorreruiz cellwallintegrityreceptormtl1contributestoarticulateautophagicresponseswhenglucoseavailabilityiscompromised
_version_	1718411655696613376

The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised

Ejemplares similares