Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats

Objectives. The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. The animals were divided into 4 experimental groups: Group 1 (Eut...

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Autores principales:	Hedayati M., Niazmand S., Hosseini M., Baghcheghi Y., Beheshti F.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	hypothyroidism oxidative stress heart aorta Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f1c18a29ef0243fb95be2cf586975f8e
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spelling	oai:doaj.org-article:f1c18a29ef0243fb95be2cf586975f8e2021-12-02T16:33:01ZVitamin E improved redox homeostasis in heart and aorta of hypothyroid rats1336-032910.1515/enr-2017-0021https://doaj.org/article/f1c18a29ef0243fb95be2cf586975f8e2017-10-01T00:00:00Zhttps://doi.org/10.1515/enr-2017-0021https://doaj.org/toc/1336-0329Objectives. The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks. Malondialdehyde (MDA) levels, total thiol levels, and the activities of Cu, Zn-superoxide dismutase (SOD) and catalase (CAT) were evaluated in the aortic and cardiac tissues. Results. A significant decrease of thyroxine (T4) serum levels confirmed hypothyroidism in rats, which received PTU. The MDA level increased and total thiol level decreased in the hypothyroid group compared to control group (p<0.001). Th e activities of SOD and CAT significantly decreased in the hypothyroid rats in comparison to the control. Vitamin E treatment resulted in increased levels of total thiol, SOD, and CAT within aortic and cardiac tissues and decreased levels of MDA in comparison with the hypothyroid group (p<0.01−p<0.001). Conclusions. PTU-induced hypothyroidism resulted in oxidative stress. Chronic administration of vitamin E to hypothyroid rats decreased the oxidative stress markers in the aortic and cardiac tissues.Hedayati M.Niazmand S.Hosseini M.Baghcheghi Y.Beheshti F.Niazmand S.Sciendoarticlehypothyroidismoxidative stressheartaortaDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 51, Iss 4, Pp 205-212 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypothyroidism oxidative stress heart aorta Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	hypothyroidism oxidative stress heart aorta Diseases of the endocrine glands. Clinical endocrinology RC648-665 Hedayati M. Niazmand S. Hosseini M. Baghcheghi Y. Beheshti F. Niazmand S. Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
description	Objectives. The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks. Malondialdehyde (MDA) levels, total thiol levels, and the activities of Cu, Zn-superoxide dismutase (SOD) and catalase (CAT) were evaluated in the aortic and cardiac tissues. Results. A significant decrease of thyroxine (T4) serum levels confirmed hypothyroidism in rats, which received PTU. The MDA level increased and total thiol level decreased in the hypothyroid group compared to control group (p<0.001). Th e activities of SOD and CAT significantly decreased in the hypothyroid rats in comparison to the control. Vitamin E treatment resulted in increased levels of total thiol, SOD, and CAT within aortic and cardiac tissues and decreased levels of MDA in comparison with the hypothyroid group (p<0.01−p<0.001). Conclusions. PTU-induced hypothyroidism resulted in oxidative stress. Chronic administration of vitamin E to hypothyroid rats decreased the oxidative stress markers in the aortic and cardiac tissues.
format	article
author	Hedayati M. Niazmand S. Hosseini M. Baghcheghi Y. Beheshti F. Niazmand S.
author_facet	Hedayati M. Niazmand S. Hosseini M. Baghcheghi Y. Beheshti F. Niazmand S.
author_sort	Hedayati M.
title	Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
title_short	Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
title_full	Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
title_fullStr	Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
title_full_unstemmed	Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats
title_sort	vitamin e improved redox homeostasis in heart and aorta of hypothyroid rats
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/f1c18a29ef0243fb95be2cf586975f8e
work_keys_str_mv	AT hedayatim vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats AT niazmands vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats AT hosseinim vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats AT baghcheghiy vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats AT beheshtif vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats AT niazmands vitamineimprovedredoxhomeostasisinheartandaortaofhypothyroidrats
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Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats

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