Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci

We investigate the suitability of statistical and model-based iterative reconstruction (IR) algorithm strengths and their influence on image quality and diagnostic performance in low-dose computer tomography (CT) protocols for lung-cancer screening procedures. We evaluate the inter- and intra-observ...

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Autores principales:	König Britta, Guberina Nika, Kühl Hilmar, Zylka Waldemar
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	ct iterative reconstruction lung nodule detection inter- and intra-observer reliability low-dose image quality phantom Medicine R
Acceso en línea:	https://doaj.org/article/f1c2a8d594844cbe97c7cd7e97811f00
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id	oai:doaj.org-article:f1c2a8d594844cbe97c7cd7e97811f00
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spelling	oai:doaj.org-article:f1c2a8d594844cbe97c7cd7e97811f002021-12-05T14:10:43ZValidation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci2364-550410.1515/cdbme-2020-3137https://doaj.org/article/f1c2a8d594844cbe97c7cd7e97811f002020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3137https://doaj.org/toc/2364-5504We investigate the suitability of statistical and model-based iterative reconstruction (IR) algorithm strengths and their influence on image quality and diagnostic performance in low-dose computer tomography (CT) protocols for lung-cancer screening procedures. We evaluate the inter- and intra-observer performance for the assessment of iterative CT reconstruction. Artificial lung foci shaped as spheres and spicules made from material with calibrated Hounsfield units were pressed within layered granules in lung lobes of an anthropomorphic phantom. Adaptively, a soft-tissue- and fat- extension ring were attached. The phantom with foci was scanned using standard high contrast, low-dose and ultra lowdose protocols. For reconstruction the IR algorithm ADMIRE at four different strength levels were used. Two ranking tests and Friedman statistics were performed. Fleiss k and modified Cohen’s kneywere used to quantify inter- and intra-observer performance. In conjunction with the standard lung kernel BL75 radiologists evaluated medium to high IR strength, with preference to S4, as suitable for lung foci detection. When varying reconstruction kernels the ranking became more random than with varying phantom diameter. The inter-observer reliability shows poor to slight agreement expressed by k<0 and k=0-0.20 . For the intra-observer reliability non- agreement with kney=0-0.20and moderate agreement with kney=0.60-0.79 for the first ranking test, and almost perfect agreement with kney>0.90 for the second ranking test was observed. In conclusion, our validation suggests radiological preference of medium to high iteration strengths, especially S4, for lung foci detection. An investigation of the correlation between diagnostic experience and the subjective perception of IR reconstructed CT images still needs to be investigated.König BrittaGuberina NikaKühl HilmarZylka WaldemarDe Gruyterarticlectiterative reconstructionlung nodule detectioninter- and intra-observer reliabilitylow-doseimage qualityphantomMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 534-537 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ct iterative reconstruction lung nodule detection inter- and intra-observer reliability low-dose image quality phantom Medicine R
spellingShingle	ct iterative reconstruction lung nodule detection inter- and intra-observer reliability low-dose image quality phantom Medicine R König Britta Guberina Nika Kühl Hilmar Zylka Waldemar Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
description	We investigate the suitability of statistical and model-based iterative reconstruction (IR) algorithm strengths and their influence on image quality and diagnostic performance in low-dose computer tomography (CT) protocols for lung-cancer screening procedures. We evaluate the inter- and intra-observer performance for the assessment of iterative CT reconstruction. Artificial lung foci shaped as spheres and spicules made from material with calibrated Hounsfield units were pressed within layered granules in lung lobes of an anthropomorphic phantom. Adaptively, a soft-tissue- and fat- extension ring were attached. The phantom with foci was scanned using standard high contrast, low-dose and ultra lowdose protocols. For reconstruction the IR algorithm ADMIRE at four different strength levels were used. Two ranking tests and Friedman statistics were performed. Fleiss k and modified Cohen’s kneywere used to quantify inter- and intra-observer performance. In conjunction with the standard lung kernel BL75 radiologists evaluated medium to high IR strength, with preference to S4, as suitable for lung foci detection. When varying reconstruction kernels the ranking became more random than with varying phantom diameter. The inter-observer reliability shows poor to slight agreement expressed by k<0 and k=0-0.20 . For the intra-observer reliability non- agreement with kney=0-0.20and moderate agreement with kney=0.60-0.79 for the first ranking test, and almost perfect agreement with kney>0.90 for the second ranking test was observed. In conclusion, our validation suggests radiological preference of medium to high iteration strengths, especially S4, for lung foci detection. An investigation of the correlation between diagnostic experience and the subjective perception of IR reconstructed CT images still needs to be investigated.
format	article
author	König Britta Guberina Nika Kühl Hilmar Zylka Waldemar
author_facet	König Britta Guberina Nika Kühl Hilmar Zylka Waldemar
author_sort	König Britta
title	Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
title_short	Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
title_full	Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
title_fullStr	Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
title_full_unstemmed	Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci
title_sort	validation of iterative ct reconstruction by inter and intra observer performance assessment of artificial lung foci
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/f1c2a8d594844cbe97c7cd7e97811f00
work_keys_str_mv	AT konigbritta validationofiterativectreconstructionbyinterandintraobserverperformanceassessmentofartificiallungfoci AT guberinanika validationofiterativectreconstructionbyinterandintraobserverperformanceassessmentofartificiallungfoci AT kuhlhilmar validationofiterativectreconstructionbyinterandintraobserverperformanceassessmentofartificiallungfoci AT zylkawaldemar validationofiterativectreconstructionbyinterandintraobserverperformanceassessmentofartificiallungfoci
_version_	1718371815922860032

Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci

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