Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017

European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these con...

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Autores principales:	Melanie M. Hierweger, Michel C. Koch, Melanie Rupp, Piet Maes, Nicholas Di Paola, Rémy Bruggmann, Jens H. Kuhn, Heike Schmidt-Posthaus, Torsten Seuberlich
Formato:	article
Lenguaje:	EN
Publicado:	Centers for Disease Control and Prevention 2021
Materias:	European perch filovirus hantavirus rhabdovirus freshwater fish viruses Medicine R Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f1c412288fad45c2ab149565cfd53ff8
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spelling	oai:doaj.org-article:f1c412288fad45c2ab149565cfd53ff82021-11-22T12:57:22ZNovel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 201710.3201/eid2712.2104911080-60401080-6059https://doaj.org/article/f1c412288fad45c2ab149565cfd53ff82021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/21-0491_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these concerns, we applied metatranscriptomics to identify disease-associated viruses in European perch farmed in Switzerland. Unexpectedly, in clinically diseased fish we detected novel freshwater fish filoviruses, a novel freshwater fish hantavirus, and a previously unknown rhabdovirus. Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. Rhabdovirus titers in organ samples were low, but virus could be isolated on cell culture. Our data add to the hypothesis that filoviruses, hantaviruses, and rhabdoviruses are globally distributed common fish commensals, pathogens, or both. Our findings shed new light on negative-sense RNA virus diversity and evolution. Melanie M. HierwegerMichel C. KochMelanie RuppPiet MaesNicholas Di PaolaRémy BruggmannJens H. KuhnHeike Schmidt-PosthausTorsten SeuberlichCenters for Disease Control and PreventionarticleEuropean perchfilovirushantavirusrhabdovirusfreshwater fishvirusesMedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3082-3091 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	European perch filovirus hantavirus rhabdovirus freshwater fish viruses Medicine R Infectious and parasitic diseases RC109-216
spellingShingle	European perch filovirus hantavirus rhabdovirus freshwater fish viruses Medicine R Infectious and parasitic diseases RC109-216 Melanie M. Hierweger Michel C. Koch Melanie Rupp Piet Maes Nicholas Di Paola Rémy Bruggmann Jens H. Kuhn Heike Schmidt-Posthaus Torsten Seuberlich Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
description	European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these concerns, we applied metatranscriptomics to identify disease-associated viruses in European perch farmed in Switzerland. Unexpectedly, in clinically diseased fish we detected novel freshwater fish filoviruses, a novel freshwater fish hantavirus, and a previously unknown rhabdovirus. Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. Rhabdovirus titers in organ samples were low, but virus could be isolated on cell culture. Our data add to the hypothesis that filoviruses, hantaviruses, and rhabdoviruses are globally distributed common fish commensals, pathogens, or both. Our findings shed new light on negative-sense RNA virus diversity and evolution.
format	article
author	Melanie M. Hierweger Michel C. Koch Melanie Rupp Piet Maes Nicholas Di Paola Rémy Bruggmann Jens H. Kuhn Heike Schmidt-Posthaus Torsten Seuberlich
author_facet	Melanie M. Hierweger Michel C. Koch Melanie Rupp Piet Maes Nicholas Di Paola Rémy Bruggmann Jens H. Kuhn Heike Schmidt-Posthaus Torsten Seuberlich
author_sort	Melanie M. Hierweger
title	Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
title_short	Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
title_full	Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
title_fullStr	Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
title_full_unstemmed	Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017
title_sort	novel filoviruses, hantavirus, and rhabdovirus in freshwater fish, switzerland, 2017
publisher	Centers for Disease Control and Prevention
publishDate	2021
url	https://doaj.org/article/f1c412288fad45c2ab149565cfd53ff8
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Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017

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