THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS

Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sayed Tanveer Abbas Gilani, Amjad Khan, Tariq Ali Khan, Muhammad Farooq
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	malarial parasite mp index platelets serum alt Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.6200 https://doaj.org/article/f1c89ce64de646c4a288f0694c020b5f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1c89ce64de646c4a288f0694c020b5f
record_format	dspace
spelling	oai:doaj.org-article:f1c89ce64de646c4a288f0694c020b5f2021-12-02T19:11:48ZTHROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTShttps://doi.org/10.51253/pafmj.v71iSuppl-1.62000030-96482411-8842https://doaj.org/article/f1c89ce64de646c4a288f0694c020b5f2021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6200https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa, from Feb 2015 to Dec 2016. Methodology: In total of 100 febrile patients of both gender and all ages reported to Pak Med Level II+ Hospital XII and XIII, Liberia with clinical features of malaria and having positive malarial parasite (MP) on any of the methods of immune chromatography (ICT) or microscopic film were included. The febrile patients with typical clinical features of malaria but having negative MP both on ICT and microscopic methods were excluded. Pretreatment whole blood in EDTA was collected for testing MP on ICT and by microscopic method including MP index and platelets, while serum for ALT. Results: Out of total 100 patients, 75 were males, 25 females with mean age of 38 ± 5 years. MP was found positive on MP film in 95% and on ICT in 88% cases. Thrombocytopenia was found in 69% and ALT was elevated in 60% cases. Mean and SD for platelets count was 129 ± 72 x 109/L and of ALT 76 ± 66 U/L. Mean of MP index was 0.49 ranging from 0 to 3.5%. Correlation of MP index with platelets and ALT was found insignificant, although in malaria patients, platelets and ALT was inversely correlated significantly with each other showing low platelets along with elevated ALT levels. Conclusion: In malaria patients, thrombocytopenia and elevated ALT are frequent findings, which may not definitely correlate with MP index. So it is advisable to test for platelet count and ALT in all patients of malaria for early diagnosis and better management.Sayed Tanveer Abbas GilaniAmjad KhanTariq Ali KhanMuhammad FarooqArmy Medical College Rawalpindiarticlemalarial parasitemp indexplateletsserum altMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 87-91 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malarial parasite mp index platelets serum alt Medicine R Medicine (General) R5-920
spellingShingle	malarial parasite mp index platelets serum alt Medicine R Medicine (General) R5-920 Sayed Tanveer Abbas Gilani Amjad Khan Tariq Ali Khan Muhammad Farooq THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
description	Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa, from Feb 2015 to Dec 2016. Methodology: In total of 100 febrile patients of both gender and all ages reported to Pak Med Level II+ Hospital XII and XIII, Liberia with clinical features of malaria and having positive malarial parasite (MP) on any of the methods of immune chromatography (ICT) or microscopic film were included. The febrile patients with typical clinical features of malaria but having negative MP both on ICT and microscopic methods were excluded. Pretreatment whole blood in EDTA was collected for testing MP on ICT and by microscopic method including MP index and platelets, while serum for ALT. Results: Out of total 100 patients, 75 were males, 25 females with mean age of 38 ± 5 years. MP was found positive on MP film in 95% and on ICT in 88% cases. Thrombocytopenia was found in 69% and ALT was elevated in 60% cases. Mean and SD for platelets count was 129 ± 72 x 109/L and of ALT 76 ± 66 U/L. Mean of MP index was 0.49 ranging from 0 to 3.5%. Correlation of MP index with platelets and ALT was found insignificant, although in malaria patients, platelets and ALT was inversely correlated significantly with each other showing low platelets along with elevated ALT levels. Conclusion: In malaria patients, thrombocytopenia and elevated ALT are frequent findings, which may not definitely correlate with MP index. So it is advisable to test for platelet count and ALT in all patients of malaria for early diagnosis and better management.
format	article
author	Sayed Tanveer Abbas Gilani Amjad Khan Tariq Ali Khan Muhammad Farooq
author_facet	Sayed Tanveer Abbas Gilani Amjad Khan Tariq Ali Khan Muhammad Farooq
author_sort	Sayed Tanveer Abbas Gilani
title	THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
title_short	THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
title_full	THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
title_fullStr	THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
title_full_unstemmed	THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS
title_sort	thrombocytopenia and elevated alanine aminotransferase levels in malaria patients
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.6200 https://doaj.org/article/f1c89ce64de646c4a288f0694c020b5f
work_keys_str_mv	AT sayedtanveerabbasgilani thrombocytopeniaandelevatedalanineaminotransferaselevelsinmalariapatients AT amjadkhan thrombocytopeniaandelevatedalanineaminotransferaselevelsinmalariapatients AT tariqalikhan thrombocytopeniaandelevatedalanineaminotransferaselevelsinmalariapatients AT muhammadfarooq thrombocytopeniaandelevatedalanineaminotransferaselevelsinmalariapatients
_version_	1718377124046307328

THROMBOCYTOPENIA AND ELEVATED ALANINE AMINOTRANSFERASE LEVELS IN MALARIA PATIENTS

Ejemplares similares