Serum Interleukin (IL)-23 and IL-17 Profile in Inflammatory Bowel Disease (IBD) Patients Could Differentiate between Severe and Non-Severe Disease

Serum Interleukin (IL)-23 and IL-17 Profile in Inflammatory Bowel Disease (IBD) Patients Could Differentiate between Severe and Non-Severe Disease

Interleukin (IL)-17 and IL-23 are crucial for mediating gut mucosal inflammation in inflammatory bowel disease (IBD), which has led to new therapeutic strategies. We assessed the relevancy of IL-17 and IL-23 serum levels as potential biomarkers towards severe IBD discrimination and disease-related c...

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Autores principales: Laura A. Lucaciu, Maria Ilieș, Ștefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
Crohn’s disease
ulcerative colitis
IBD severity
interleukin-17
interleukin-23
biomarker
Medicine
R
Acceso en línea:https://doaj.org/article/f1c8d307f70440e395d642eebdfde893
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Sumario:Interleukin (IL)-17 and IL-23 are crucial for mediating gut mucosal inflammation in inflammatory bowel disease (IBD), which has led to new therapeutic strategies. We assessed the relevancy of IL-17 and IL-23 serum levels as potential biomarkers towards severe IBD discrimination and disease-related complications. Sixty-two patients diagnosed with Crohn’s disease (CD) and ulcerative colitis (UC) were included. Serum IL-17 and IL-23 were measured by sandwich enzyme-linked immunosorbent assays (ELISA). IL-23 and fecal calprotectin (FCal) were significantly higher in severe CD (<i>p</i> < 0.001) and UC (<i>p</i> < 0.001 and <i>p</i> = 0.001, respectively), compared to mild or moderate. Elevated C-reactive protein (CRP) was correlated with severe disease only in CD (<i>p</i> = 0.008), whereas for UC, disease severity was associated with increased IL-17 values (<i>p</i> < 0.001). Diagnostic role of IL-23 was superior to FCal in discriminating between severe and mild to moderate CD (<i>p</i> < 0.001). IL-23 levels were also significantly higher in CD patients with intestinal complications (<i>p</i> = 0.04). Both IL-17 and IL-23 correlate with IBD severity, and IL-23 might be a promising novel biomarker for severe CD. Identifying the dominant IL pathway involved in IBD severity could serve as guidance for clinical decision-making on biologic therapy.

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