Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk

Abstract Appraisal of muscle mass is important when considering the serious consequences of sarcopenia in an aging society. However, the associations between sarcopenia and its clinical outcomes might vary according to the method applied in its diagnosis. We compared the relationships between cardio...

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Autores principales:	Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1cafff268504b4f8201b942e5d5196d
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spelling	oai:doaj.org-article:f1cafff268504b4f8201b942e5d5196d2021-12-02T11:52:57ZComparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk10.1038/s41598-017-06831-72045-2322https://doaj.org/article/f1cafff268504b4f8201b942e5d5196d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06831-7https://doaj.org/toc/2045-2322Abstract Appraisal of muscle mass is important when considering the serious consequences of sarcopenia in an aging society. However, the associations between sarcopenia and its clinical outcomes might vary according to the method applied in its diagnosis. We compared the relationships between cardiometabolic risk parameters and sarcopenia defined according to three different diagnostic methods using dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Appendicular skeletal muscle mass (ASM) adjusted by height squared and BMI (ASM/height2 and ASM/BMI) measured using DXA and thigh muscle cross-sectional area (tmCSA) adjusted by weight (tmCSA/weight) measured using CT were used as indices of muscle mass. Sarcopenia was defined as two standard deviations below either the mean ASM/height2, ASM/BMI, or tmCSA/weight of a young reference group. ASM/BMI and tmCSA/weight showed a negative relationship with several components of metabolic syndrome and HOMA-IR, whereas ASM/height2 was positively associated with theses cardiometabolic risk factors. Logistic regression analyses demonstrated that ASM/BMI-defined sarcopenia was significantly associated with increased HOMA-IR (P = 0.01) and prevalence of visceral obesity (P = 0.03) and metabolic syndrome (P = 0.025), while ASM/height2- and tmCSA/weight-defined sarcopenia were not. ASM/BMI-defined sarcopenia exhibits a closer relationship with cardiometabolic risk factors than does ASM/height2- or tmCSA/weight-defined sarcopenia.Tae Nyun KimMan Sik ParkEun Joo LeeHye Soo ChungHye Jin YooHyun Joo KangWook SongSei Hyun BaikKyung Mook ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae Nyun Kim Man Sik Park Eun Joo Lee Hye Soo Chung Hye Jin Yoo Hyun Joo Kang Wook Song Sei Hyun Baik Kyung Mook Choi Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
description	Abstract Appraisal of muscle mass is important when considering the serious consequences of sarcopenia in an aging society. However, the associations between sarcopenia and its clinical outcomes might vary according to the method applied in its diagnosis. We compared the relationships between cardiometabolic risk parameters and sarcopenia defined according to three different diagnostic methods using dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Appendicular skeletal muscle mass (ASM) adjusted by height squared and BMI (ASM/height2 and ASM/BMI) measured using DXA and thigh muscle cross-sectional area (tmCSA) adjusted by weight (tmCSA/weight) measured using CT were used as indices of muscle mass. Sarcopenia was defined as two standard deviations below either the mean ASM/height2, ASM/BMI, or tmCSA/weight of a young reference group. ASM/BMI and tmCSA/weight showed a negative relationship with several components of metabolic syndrome and HOMA-IR, whereas ASM/height2 was positively associated with theses cardiometabolic risk factors. Logistic regression analyses demonstrated that ASM/BMI-defined sarcopenia was significantly associated with increased HOMA-IR (P = 0.01) and prevalence of visceral obesity (P = 0.03) and metabolic syndrome (P = 0.025), while ASM/height2- and tmCSA/weight-defined sarcopenia were not. ASM/BMI-defined sarcopenia exhibits a closer relationship with cardiometabolic risk factors than does ASM/height2- or tmCSA/weight-defined sarcopenia.
format	article
author	Tae Nyun Kim Man Sik Park Eun Joo Lee Hye Soo Chung Hye Jin Yoo Hyun Joo Kang Wook Song Sei Hyun Baik Kyung Mook Choi
author_facet	Tae Nyun Kim Man Sik Park Eun Joo Lee Hye Soo Chung Hye Jin Yoo Hyun Joo Kang Wook Song Sei Hyun Baik Kyung Mook Choi
author_sort	Tae Nyun Kim
title	Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
title_short	Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
title_full	Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
title_fullStr	Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
title_full_unstemmed	Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
title_sort	comparisons of three different methods for defining sarcopenia: an aspect of cardiometabolic risk
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f1cafff268504b4f8201b942e5d5196d
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_version_	1718394960984670208

Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk

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