Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.

<h4>Background</h4>In Kenya, the comparative incidences of tuberculosis among persons with and without HIV have not been described, and the differential impact of public health interventions on tuberculosis incidence in the two groups is unknown.<h4>Methods</h4>We estimated a...

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Autores principales:	Courtney M Yuen, Herman O Weyenga, Andrea A Kim, Timothy Malika, Hellen Muttai, Abraham Katana, Lucy Nganga, Kevin P Cain, Kevin M De Cock
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1cc874c6a7443938c79b3cc37368fd6
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spelling	oai:doaj.org-article:f1cc874c6a7443938c79b3cc37368fd62021-11-18T08:15:16ZComparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.1932-620310.1371/journal.pone.0099880https://doaj.org/article/f1cc874c6a7443938c79b3cc37368fd62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24937804/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In Kenya, the comparative incidences of tuberculosis among persons with and without HIV have not been described, and the differential impact of public health interventions on tuberculosis incidence in the two groups is unknown.<h4>Methods</h4>We estimated annual tuberculosis incidence stratified by HIV status during 2006-2012 based on the numbers of reported tuberculosis patients with and without HIV infection, the prevalence of HIV infection in the general population, and the total population. We also made crude estimates of annual tuberculosis incidence stratified by HIV status during 1998-2012 by assuming a constant ratio of HIV prevalence among tuberculosis patients compared to the general population.<h4>Results</h4>Tuberculosis incidence among both adults with HIV and adults without HIV increased during 1998-2004 then remained relatively stable until 2007. During 2007-2012, tuberculosis incidence declined by 28-44% among adults with HIV and by 11-26% among adults without HIV, concurrent with an increase in antiretroviral therapy uptake. In 2012, tuberculosis incidence among adults with HIV (1,839-1,936 cases/100,000 population) was still eight times as high as among adults without HIV (231-238 cases/100,000 population), and approximately one third of tuberculosis cases were attributable to HIV.<h4>Conclusions</h4>Although tuberculosis incidence has declined among adults with and without HIV, the persistent high incidence of tuberculosis among those with HIV and the disparity between the two groups are concerning. Early diagnosis of HIV, early initiation of antiretroviral therapy, regular screening for tuberculosis, and isoniazid preventive therapy among persons with HIV, as well as tuberculosis control in the general population, are required to address these issues.Courtney M YuenHerman O WeyengaAndrea A KimTimothy MalikaHellen MuttaiAbraham KatanaLucy NgangaKevin P CainKevin M De CockPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99880 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Courtney M Yuen Herman O Weyenga Andrea A Kim Timothy Malika Hellen Muttai Abraham Katana Lucy Nganga Kevin P Cain Kevin M De Cock Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
description	<h4>Background</h4>In Kenya, the comparative incidences of tuberculosis among persons with and without HIV have not been described, and the differential impact of public health interventions on tuberculosis incidence in the two groups is unknown.<h4>Methods</h4>We estimated annual tuberculosis incidence stratified by HIV status during 2006-2012 based on the numbers of reported tuberculosis patients with and without HIV infection, the prevalence of HIV infection in the general population, and the total population. We also made crude estimates of annual tuberculosis incidence stratified by HIV status during 1998-2012 by assuming a constant ratio of HIV prevalence among tuberculosis patients compared to the general population.<h4>Results</h4>Tuberculosis incidence among both adults with HIV and adults without HIV increased during 1998-2004 then remained relatively stable until 2007. During 2007-2012, tuberculosis incidence declined by 28-44% among adults with HIV and by 11-26% among adults without HIV, concurrent with an increase in antiretroviral therapy uptake. In 2012, tuberculosis incidence among adults with HIV (1,839-1,936 cases/100,000 population) was still eight times as high as among adults without HIV (231-238 cases/100,000 population), and approximately one third of tuberculosis cases were attributable to HIV.<h4>Conclusions</h4>Although tuberculosis incidence has declined among adults with and without HIV, the persistent high incidence of tuberculosis among those with HIV and the disparity between the two groups are concerning. Early diagnosis of HIV, early initiation of antiretroviral therapy, regular screening for tuberculosis, and isoniazid preventive therapy among persons with HIV, as well as tuberculosis control in the general population, are required to address these issues.
format	article
author	Courtney M Yuen Herman O Weyenga Andrea A Kim Timothy Malika Hellen Muttai Abraham Katana Lucy Nganga Kevin P Cain Kevin M De Cock
author_facet	Courtney M Yuen Herman O Weyenga Andrea A Kim Timothy Malika Hellen Muttai Abraham Katana Lucy Nganga Kevin P Cain Kevin M De Cock
author_sort	Courtney M Yuen
title	Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
title_short	Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
title_full	Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
title_fullStr	Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
title_full_unstemmed	Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
title_sort	comparison of trends in tuberculosis incidence among adults living with hiv and adults without hiv--kenya, 1998-2012.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f1cc874c6a7443938c79b3cc37368fd6
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Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.

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