Geographical differences in semen characteristics of 13 892 infertile men

Objective: To assess the relationship between geographical differences and all semen parameters, across 13,892 infertile men of 84 diverse nationalities, recruited at a specialised tertiary hospital that represents the main healthcare provider in Qatar. Male infertility is an important and global pu...

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Autores principales:	Haitham Elbardisi, Ahmad Majzoub, Sami Al Said, Khalid Al Rumaihi, Walid El Ansari, Alia Alattar, Mohamed Arafa
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/f1cc9acc3e2647dabbe822c5dc2d5ab5
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spelling	oai:doaj.org-article:f1cc9acc3e2647dabbe822c5dc2d5ab52021-12-02T12:24:08ZGeographical differences in semen characteristics of 13 892 infertile men2090-598X10.1016/j.aju.2017.11.018https://doaj.org/article/f1cc9acc3e2647dabbe822c5dc2d5ab52018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18300020https://doaj.org/toc/2090-598XObjective: To assess the relationship between geographical differences and all semen parameters, across 13,892 infertile men of 84 diverse nationalities, recruited at a specialised tertiary hospital that represents the main healthcare provider in Qatar. Male infertility is an important and global public health problem. Despite this, there is a significant scarcity of epidemiological male infertility and semen analysis research in the Middle East and North Africa (MENA) region, as well as geographical comparisons with other parts of the world. Patients and methods: Retrospective study of semen findings of 13 892 infertile men assessed at the Male Infertility Unit at Hamad Medical Corporation, in Qatar between January 2012 and August 2015. Based on country of origin, patients were categorised into those from the MENA region (n = 8799) and non-MENA patients (n = 5093). The two groups were compared across demographic features and semen characteristics: age, sperm volume, sperm total motility, sperm progressive motility (PMot), abnormal sperm forms (ABF), and sperm DNA fragmentation (SDF). Results: The whole sample’s mean (SD) age was 35.7 (0.7) years, sperm concentration was 32.3 (0.25) × 106 sperm/mL, total motility was 45.4 (0.2)%, sperm PMot was 25.1 (0.2)%, and ABF was 79.9 (0.2)%. Overall, 841 patients had azoospermia (6.05%), 3231 had oligospermia (23.3%), 4239 had asthenospermia (30.5%) and 6772 had teratospermia (48.7%). SDF (1050 patients) was abnormal in 333 patients (31.7%). MENA patients were significantly younger than their non-MENA counterparts and had a greater semen volume. Non-MENA patients had significantly higher sperm counts, total motility and PMot, and lower ABF. SDF showed no statistical difference between the two groups. MENA patients had significantly higher prevalence of oligospermia, asthenospermia, and teratospermia; and lower prevalence of normal sperm concentration, normal motility, and normal morphology. Throughout the 4 years of the study, MENA patients constantly had significantly lower sperm counts; generally lower sperm total motility percentage and generally lower quality sperm morphology. We compared patients by age (≤40 and >40 years): in the patients aged ≤40 years, the same results as for the overall study were reproduced; in the >40-years group, the same results were reproduced with the exception of morphology, which was not significantly different between the MENA and non-MENA patients. Conclusion: Semen quality is generally lower in male infertility patients from the MENA region compared to non-MENA regions. Keywords: Male infertility, MENA, Semen quality, Sperm DNA fragmentationHaitham ElbardisiAhmad MajzoubSami Al SaidKhalid Al RumaihiWalid El AnsariAlia AlattarMohamed ArafaTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 3-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Haitham Elbardisi Ahmad Majzoub Sami Al Said Khalid Al Rumaihi Walid El Ansari Alia Alattar Mohamed Arafa Geographical differences in semen characteristics of 13 892 infertile men
description	Objective: To assess the relationship between geographical differences and all semen parameters, across 13,892 infertile men of 84 diverse nationalities, recruited at a specialised tertiary hospital that represents the main healthcare provider in Qatar. Male infertility is an important and global public health problem. Despite this, there is a significant scarcity of epidemiological male infertility and semen analysis research in the Middle East and North Africa (MENA) region, as well as geographical comparisons with other parts of the world. Patients and methods: Retrospective study of semen findings of 13 892 infertile men assessed at the Male Infertility Unit at Hamad Medical Corporation, in Qatar between January 2012 and August 2015. Based on country of origin, patients were categorised into those from the MENA region (n = 8799) and non-MENA patients (n = 5093). The two groups were compared across demographic features and semen characteristics: age, sperm volume, sperm total motility, sperm progressive motility (PMot), abnormal sperm forms (ABF), and sperm DNA fragmentation (SDF). Results: The whole sample’s mean (SD) age was 35.7 (0.7) years, sperm concentration was 32.3 (0.25) × 106 sperm/mL, total motility was 45.4 (0.2)%, sperm PMot was 25.1 (0.2)%, and ABF was 79.9 (0.2)%. Overall, 841 patients had azoospermia (6.05%), 3231 had oligospermia (23.3%), 4239 had asthenospermia (30.5%) and 6772 had teratospermia (48.7%). SDF (1050 patients) was abnormal in 333 patients (31.7%). MENA patients were significantly younger than their non-MENA counterparts and had a greater semen volume. Non-MENA patients had significantly higher sperm counts, total motility and PMot, and lower ABF. SDF showed no statistical difference between the two groups. MENA patients had significantly higher prevalence of oligospermia, asthenospermia, and teratospermia; and lower prevalence of normal sperm concentration, normal motility, and normal morphology. Throughout the 4 years of the study, MENA patients constantly had significantly lower sperm counts; generally lower sperm total motility percentage and generally lower quality sperm morphology. We compared patients by age (≤40 and >40 years): in the patients aged ≤40 years, the same results as for the overall study were reproduced; in the >40-years group, the same results were reproduced with the exception of morphology, which was not significantly different between the MENA and non-MENA patients. Conclusion: Semen quality is generally lower in male infertility patients from the MENA region compared to non-MENA regions. Keywords: Male infertility, MENA, Semen quality, Sperm DNA fragmentation
format	article
author	Haitham Elbardisi Ahmad Majzoub Sami Al Said Khalid Al Rumaihi Walid El Ansari Alia Alattar Mohamed Arafa
author_facet	Haitham Elbardisi Ahmad Majzoub Sami Al Said Khalid Al Rumaihi Walid El Ansari Alia Alattar Mohamed Arafa
author_sort	Haitham Elbardisi
title	Geographical differences in semen characteristics of 13 892 infertile men
title_short	Geographical differences in semen characteristics of 13 892 infertile men
title_full	Geographical differences in semen characteristics of 13 892 infertile men
title_fullStr	Geographical differences in semen characteristics of 13 892 infertile men
title_full_unstemmed	Geographical differences in semen characteristics of 13 892 infertile men
title_sort	geographical differences in semen characteristics of 13 892 infertile men
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/f1cc9acc3e2647dabbe822c5dc2d5ab5
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Geographical differences in semen characteristics of 13 892 infertile men

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