Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T ce...

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Autores principales:	Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1cf2521c0344d9887bd758bdb76df35
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spelling	oai:doaj.org-article:f1cf2521c0344d9887bd758bdb76df352021-12-02T14:39:34ZProtein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-110.1038/ncomms127562041-1723https://doaj.org/article/f1cf2521c0344d9887bd758bdb76df352016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12756https://doaj.org/toc/2041-1723The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.Eri IshikawaHidetaka KosakoTomoharu YasudaMasaki OhmurayaKimi ArakiTomohiro KurosakiTakashi SaitoSho YamasakiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
description	The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.
format	article
author	Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki
author_facet	Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki
author_sort	Eri Ishikawa
title	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_short	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_full	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_fullStr	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_full_unstemmed	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_sort	protein kinase d regulates positive selection of cd4+ thymocytes through phosphorylation of shp-1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f1cf2521c0344d9887bd758bdb76df35
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Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

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