Alleviation of Malathion Toxicity Effect by Coffea arabica L. Oil and Olea europaea L. Oil on Lipid Profile: Physiological and In Silico Study

The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of Coffea arabica L. oil and Olea europaea L. oil on MAL-intoxicate...

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Autores principales:	Khalid M. Al-Asmari, Isam M. Abu Zeid, Hisham N. Altayb, Atef M. Al-Attar, Mohammed Y. Alomar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	malathion <i>Coffea arabica</i> oil <i>Olea europaea</i> oil lipid profile chlorogenic acid oleuropein Botany QK1-989
Acceso en línea:	https://doaj.org/article/f1d654db5c5c4243a42ff2f7d8924692
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spelling	oai:doaj.org-article:f1d654db5c5c4243a42ff2f7d89246922021-11-25T18:45:11ZAlleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study10.3390/plants101123142223-7747https://doaj.org/article/f1d654db5c5c4243a42ff2f7d89246922021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2314https://doaj.org/toc/2223-7747The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil on MAL-intoxicated male rats. Six equal groups of animals were used for conducting this study (<i>n</i> = 10). Animals in group one were designated as control, animals belonging to group two were exposed to MAL in the measure of hundred mg per kg BW (body weight) for forty-nine days (seven weeks), rats in the third and fourth groups were administered with 400 mg/kg BW of <i>Coffea arabica</i> L. and <i>Olea europaea</i> L. oils, respectively, and the same amount of MAL as given to the second group. Groups five and six were administered with the same amount of <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil as given to group three. Exposure of rats to 100 mg/kg body weight of MAL resulted in statistical alteration of the serum lipid profile. A marked decline was noticed in the severe changes of these blood parameters when MAL-intoxicated rats were treated with <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil. Two compounds from <i>Coffea arabica</i> L. oil (Chlorogenic acid) and <i>Olea europaea</i> L. oil (Oleuropein) demonstrated good interaction with xanthine oxidase (XO) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) enzymes that are associated with cholesterol production. The present study indicated that <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil could be considered prospective and potential healing agents against metabolic conditions induced by MAL.Khalid M. Al-AsmariIsam M. Abu ZeidHisham N. AltaybAtef M. Al-AttarMohammed Y. AlomarMDPI AGarticlemalathion<i>Coffea arabica</i> oil<i>Olea europaea</i> oillipid profilechlorogenic acidoleuropeinBotanyQK1-989ENPlants, Vol 10, Iss 2314, p 2314 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malathion <i>Coffea arabica</i> oil <i>Olea europaea</i> oil lipid profile chlorogenic acid oleuropein Botany QK1-989
spellingShingle	malathion <i>Coffea arabica</i> oil <i>Olea europaea</i> oil lipid profile chlorogenic acid oleuropein Botany QK1-989 Khalid M. Al-Asmari Isam M. Abu Zeid Hisham N. Altayb Atef M. Al-Attar Mohammed Y. Alomar Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
description	The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil on MAL-intoxicated male rats. Six equal groups of animals were used for conducting this study (<i>n</i> = 10). Animals in group one were designated as control, animals belonging to group two were exposed to MAL in the measure of hundred mg per kg BW (body weight) for forty-nine days (seven weeks), rats in the third and fourth groups were administered with 400 mg/kg BW of <i>Coffea arabica</i> L. and <i>Olea europaea</i> L. oils, respectively, and the same amount of MAL as given to the second group. Groups five and six were administered with the same amount of <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil as given to group three. Exposure of rats to 100 mg/kg body weight of MAL resulted in statistical alteration of the serum lipid profile. A marked decline was noticed in the severe changes of these blood parameters when MAL-intoxicated rats were treated with <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil. Two compounds from <i>Coffea arabica</i> L. oil (Chlorogenic acid) and <i>Olea europaea</i> L. oil (Oleuropein) demonstrated good interaction with xanthine oxidase (XO) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) enzymes that are associated with cholesterol production. The present study indicated that <i>Coffea arabica</i> L. oil and <i>Olea europaea</i> L. oil could be considered prospective and potential healing agents against metabolic conditions induced by MAL.
format	article
author	Khalid M. Al-Asmari Isam M. Abu Zeid Hisham N. Altayb Atef M. Al-Attar Mohammed Y. Alomar
author_facet	Khalid M. Al-Asmari Isam M. Abu Zeid Hisham N. Altayb Atef M. Al-Attar Mohammed Y. Alomar
author_sort	Khalid M. Al-Asmari
title	Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
title_short	Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
title_full	Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
title_fullStr	Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
title_full_unstemmed	Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study
title_sort	alleviation of malathion toxicity effect by <i>coffea arabica</i> l. oil and <i>olea europaea</i> l. oil on lipid profile: physiological and in silico study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1d654db5c5c4243a42ff2f7d8924692
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Alleviation of Malathion Toxicity Effect by <i>Coffea arabica</i> L. Oil and <i>Olea europaea</i> L. Oil on Lipid Profile: Physiological and In Silico Study

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