Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol

Abstract The specific concentrations of florfenicol and thiamphenicol in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Dan I Andersson, Vasileios Bampidis, Johan Bengtsson‐Palme, Damien Bouchard, Aude Ferran, Maryline Kouba, Secundino López Puente, Marta López‐Alonso, Søren Saxmose Nielsen, Alena Pechová, Mariana Petkova, Sebastien Girault, Alessandro Broglia, Beatriz Guerra, Matteo Lorenzo Innocenti, Ernesto Liébana, Gloria López‐Gálvez, Paola Manini, Pietro Stella, Luisa Peixe
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	florfenicol thiamphenicol antimicrobial resistance sub‐inhibitory concentration growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/f1d73e869cf44d7d814c3cc6a344854f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1d73e869cf44d7d814c3cc6a344854f
record_format	dspace
spelling	oai:doaj.org-article:f1d73e869cf44d7d814c3cc6a344854f2021-11-23T08:30:51ZMaximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol1831-473210.2903/j.efsa.2021.6859https://doaj.org/article/f1d73e869cf44d7d814c3cc6a344854f2021-10-01T00:00:00Zhttps://doi.org/10.2903/j.efsa.2021.6859https://doaj.org/toc/1831-4732Abstract The specific concentrations of florfenicol and thiamphenicol in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for florfenicol was estimated. However, due to the lack of data, the calculation of the FARSC for thiamphenicol was not possible until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for florfenicol, whilst for thiamphenicol no suitable data for the assessment were available. Uncertainties and data gaps associated to the levels reported were addressed. For florfenicol, it was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC, whereas for thiamphenicol, the recommendation was to generate the data required to fill the gaps which prevented the FARSC calculation.EFSA Panel on Biological Hazards (BIOHAZ)Konstantinos KoutsoumanisAna AllendeAvelino Alvarez‐OrdóñezDeclan BoltonSara Bover‐CidMarianne ChemalyRobert DaviesAlessandra De CesareLieve HermanFriederike HilbertRoland LindqvistMaarten NautaGiuseppe RuMarion SimmonsPanagiotis SkandamisElisabetta SuffrediniDan I AnderssonVasileios BampidisJohan Bengtsson‐PalmeDamien BouchardAude FerranMaryline KoubaSecundino López PuenteMarta López‐AlonsoSøren Saxmose NielsenAlena PechováMariana PetkovaSebastien GiraultAlessandro BrogliaBeatriz GuerraMatteo Lorenzo InnocentiErnesto LiébanaGloria López‐GálvezPaola ManiniPietro StellaLuisa PeixeWileyarticleflorfenicolthiamphenicolantimicrobial resistancesub‐inhibitory concentrationgrowth promotionyield increaseNutrition. Foods and food supplyTX341-641Chemical technologyTP1-1185ENEFSA Journal, Vol 19, Iss 10, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	florfenicol thiamphenicol antimicrobial resistance sub‐inhibitory concentration growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
spellingShingle	florfenicol thiamphenicol antimicrobial resistance sub‐inhibitory concentration growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
description	Abstract The specific concentrations of florfenicol and thiamphenicol in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for florfenicol was estimated. However, due to the lack of data, the calculation of the FARSC for thiamphenicol was not possible until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for florfenicol, whilst for thiamphenicol no suitable data for the assessment were available. Uncertainties and data gaps associated to the levels reported were addressed. For florfenicol, it was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC, whereas for thiamphenicol, the recommendation was to generate the data required to fill the gaps which prevented the FARSC calculation.
format	article
author	EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe
author_facet	EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe
author_sort	EFSA Panel on Biological Hazards (BIOHAZ)
title	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
title_short	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
title_full	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
title_fullStr	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
title_full_unstemmed	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol
title_sort	maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. part 7: amphenicols: florfenicol and thiamphenicol
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f1d73e869cf44d7d814c3cc6a344854f
work_keys_str_mv	AT efsapanelonbiologicalhazardsbiohaz maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT konstantinoskoutsoumanis maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT anaallende maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT avelinoalvarezordonez maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT declanbolton maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT sarabovercid maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT mariannechemaly maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT robertdavies maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT alessandradecesare maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT lieveherman maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT friederikehilbert maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT rolandlindqvist maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT maartennauta maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT giusepperu maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT marionsimmons maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT panagiotisskandamis maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT elisabettasuffredini maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT daniandersson maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT vasileiosbampidis maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT johanbengtssonpalme maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT damienbouchard maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT audeferran maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT marylinekouba maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT secundinolopezpuente maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT martalopezalonso maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT sørensaxmosenielsen maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT alenapechova maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT marianapetkova maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT sebastiengirault maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT alessandrobroglia maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT beatrizguerra maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT matteolorenzoinnocenti maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT ernestoliebana maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT glorialopezgalvez maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT paolamanini maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT pietrostella maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol AT luisapeixe maximumlevelsofcrosscontaminationfor24antimicrobialactivesubstancesinnontargetfeedpart7amphenicolsflorfenicolandthiamphenicol
_version_	1718416860260597760

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 7: Amphenicols: florfenicol and thiamphenicol

Ejemplares similares