Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.

Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic ca...

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Autores principales:	Ayako Okada, Takatoshi Murata, Khairul Matin, Meu Ariyoshi, Ryoko Otsuka, Mamiko Yamashita, Masayuki Suzuki, Rumi Wakiyama, Ken Tateno, Megumi Suzuki, Hitomi Aoyagi, Hiromi Uematsu, Akiko Imamura, Miki Kosaka, Tomoko Mizukaki, Tsutomu Sato, Hiroshi Kawahara, Nobuhiro Hanada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1d8fd3cff594ae5902f131937a89bb2
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spelling	oai:doaj.org-article:f1d8fd3cff594ae5902f131937a89bb22021-12-02T20:06:11ZEffect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.1932-620310.1371/journal.pone.0257247https://doaj.org/article/f1d8fd3cff594ae5902f131937a89bb22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257247https://doaj.org/toc/1932-6203Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, -0.1%; 95% confidence interval [CI], -1.0-0.8; P = 0.805) or test (mean increase, -0.3%; 95% CI, -1.1-0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, -0.00-0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, -0.01-0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, -0.2%; 95% CI, -1.4-0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, -0.00-0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).Ayako OkadaTakatoshi MurataKhairul MatinMeu AriyoshiRyoko OtsukaMamiko YamashitaMasayuki SuzukiRumi WakiyamaKen TatenoMegumi SuzukiHitomi AoyagiHiromi UematsuAkiko ImamuraMiki KosakaTomoko MizukakiTsutomu SatoHiroshi KawaharaNobuhiro HanadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257247 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayako Okada Takatoshi Murata Khairul Matin Meu Ariyoshi Ryoko Otsuka Mamiko Yamashita Masayuki Suzuki Rumi Wakiyama Ken Tateno Megumi Suzuki Hitomi Aoyagi Hiromi Uematsu Akiko Imamura Miki Kosaka Tomoko Mizukaki Tsutomu Sato Hiroshi Kawahara Nobuhiro Hanada Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
description	Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, -0.1%; 95% confidence interval [CI], -1.0-0.8; P = 0.805) or test (mean increase, -0.3%; 95% CI, -1.1-0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, -0.00-0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, -0.01-0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, -0.2%; 95% CI, -1.4-0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, -0.00-0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
format	article
author	Ayako Okada Takatoshi Murata Khairul Matin Meu Ariyoshi Ryoko Otsuka Mamiko Yamashita Masayuki Suzuki Rumi Wakiyama Ken Tateno Megumi Suzuki Hitomi Aoyagi Hiromi Uematsu Akiko Imamura Miki Kosaka Tomoko Mizukaki Tsutomu Sato Hiroshi Kawahara Nobuhiro Hanada
author_facet	Ayako Okada Takatoshi Murata Khairul Matin Meu Ariyoshi Ryoko Otsuka Mamiko Yamashita Masayuki Suzuki Rumi Wakiyama Ken Tateno Megumi Suzuki Hitomi Aoyagi Hiromi Uematsu Akiko Imamura Miki Kosaka Tomoko Mizukaki Tsutomu Sato Hiroshi Kawahara Nobuhiro Hanada
author_sort	Ayako Okada
title	Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
title_short	Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
title_full	Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
title_fullStr	Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
title_full_unstemmed	Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
title_sort	effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: an open-label, randomized controlled trial.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f1d8fd3cff594ae5902f131937a89bb2
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Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.

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