Identification and characterization of two functional variants in the human longevity gene FOXO3
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.
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Nature Portfolio
2017
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oai:doaj.org-article:f1d90b23cde74314abd23e1b467785a02021-12-02T17:06:25ZIdentification and characterization of two functional variants in the human longevity gene FOXO310.1038/s41467-017-02183-y2041-1723https://doaj.org/article/f1d90b23cde74314abd23e1b467785a02017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02183-yhttps://doaj.org/toc/2041-1723FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.Friederike FlachsbartJanina DoseLiljana GentschewClaudia GeismannAmke CaliebeCarolin KnechtMarianne NygaardNandini BadarinarayanAbdou ElSharawySandra MayAnne LuziusGuillermo G. TorresMarlene JentzschMichael ForsterRobert HäslerKathrin PallaufWolfgang LiebCéline DerboisPilar GalanDmitriy DrichelAlexander ArltAndreas TillBen Krause-KyoraGerald RimbachHélène BlanchéJean-François DeleuzeLene ChristiansenKaare ChristensenMichael NothnagelPhilip RosenstielStefan SchreiberAndre FrankeSusanne SebensAlmut NebelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
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EN |
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Science Q |
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Science Q Friederike Flachsbart Janina Dose Liljana Gentschew Claudia Geismann Amke Caliebe Carolin Knecht Marianne Nygaard Nandini Badarinarayan Abdou ElSharawy Sandra May Anne Luzius Guillermo G. Torres Marlene Jentzsch Michael Forster Robert Häsler Kathrin Pallauf Wolfgang Lieb Céline Derbois Pilar Galan Dmitriy Drichel Alexander Arlt Andreas Till Ben Krause-Kyora Gerald Rimbach Hélène Blanché Jean-François Deleuze Lene Christiansen Kaare Christensen Michael Nothnagel Philip Rosenstiel Stefan Schreiber Andre Franke Susanne Sebens Almut Nebel Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| description |
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression. |
| format |
article |
| author |
Friederike Flachsbart Janina Dose Liljana Gentschew Claudia Geismann Amke Caliebe Carolin Knecht Marianne Nygaard Nandini Badarinarayan Abdou ElSharawy Sandra May Anne Luzius Guillermo G. Torres Marlene Jentzsch Michael Forster Robert Häsler Kathrin Pallauf Wolfgang Lieb Céline Derbois Pilar Galan Dmitriy Drichel Alexander Arlt Andreas Till Ben Krause-Kyora Gerald Rimbach Hélène Blanché Jean-François Deleuze Lene Christiansen Kaare Christensen Michael Nothnagel Philip Rosenstiel Stefan Schreiber Andre Franke Susanne Sebens Almut Nebel |
| author_facet |
Friederike Flachsbart Janina Dose Liljana Gentschew Claudia Geismann Amke Caliebe Carolin Knecht Marianne Nygaard Nandini Badarinarayan Abdou ElSharawy Sandra May Anne Luzius Guillermo G. Torres Marlene Jentzsch Michael Forster Robert Häsler Kathrin Pallauf Wolfgang Lieb Céline Derbois Pilar Galan Dmitriy Drichel Alexander Arlt Andreas Till Ben Krause-Kyora Gerald Rimbach Hélène Blanché Jean-François Deleuze Lene Christiansen Kaare Christensen Michael Nothnagel Philip Rosenstiel Stefan Schreiber Andre Franke Susanne Sebens Almut Nebel |
| author_sort |
Friederike Flachsbart |
| title |
Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| title_short |
Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| title_full |
Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| title_fullStr |
Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| title_full_unstemmed |
Identification and characterization of two functional variants in the human longevity gene FOXO3 |
| title_sort |
identification and characterization of two functional variants in the human longevity gene foxo3 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0 |
| work_keys_str_mv |
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