Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy

Abstract Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the d...

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Autores principales:	Wen-Chin Weng, Po-Hsiang Tsui, Chia-Wei Lin, Chun-Hao Lu, Chun-Yen Lin, Jeng-Yi Shieh, Frank Leigh Lu, Ting-Wei Ee, Kuan-Wen Wu, Wang-Tso Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1d9b02298cb4b5a9c21cbea2855b7c5
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spelling	oai:doaj.org-article:f1d9b02298cb4b5a9c21cbea2855b7c52021-12-02T15:06:12ZEvaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy10.1038/s41598-017-04131-82045-2322https://doaj.org/article/f1d9b02298cb4b5a9c21cbea2855b7c52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04131-8https://doaj.org/toc/2045-2322Abstract Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory). All participants underwent ultrasound examinations on the rectus femoris, tibialis anterior, and gastrocnemius. The results revealed that the ultrasound Nakagami parameter correlated positively with functional severity in the patients with DMD. The median Nakagami parameter of the gastrocnemius muscle increased from 0.50 to 0.85, corresponding to the largest dynamic range between normal and stage 3. The accuracy, sensitivity, and specificity of diagnosing walking function were 85.52%, 76.31%, and 94.73%, respectively. The Nakagami parameter of the rectus femoris and gastrocnemius muscles correlated negatively with the 6-minute walking distance in the ambulatory patients. Therefore, changes in the Nakagami parameter for the gastrocnemius muscle are suitable for monitoring disease progression in ambulatory patients and for predicting ambulation loss. Ultrasound Nakagami imaging shows potential for evaluating patients with DMD.Wen-Chin WengPo-Hsiang TsuiChia-Wei LinChun-Hao LuChun-Yen LinJeng-Yi ShiehFrank Leigh LuTing-Wei EeKuan-Wen WuWang-Tso LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen-Chin Weng Po-Hsiang Tsui Chia-Wei Lin Chun-Hao Lu Chun-Yen Lin Jeng-Yi Shieh Frank Leigh Lu Ting-Wei Ee Kuan-Wen Wu Wang-Tso Lee Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
description	Abstract Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory). All participants underwent ultrasound examinations on the rectus femoris, tibialis anterior, and gastrocnemius. The results revealed that the ultrasound Nakagami parameter correlated positively with functional severity in the patients with DMD. The median Nakagami parameter of the gastrocnemius muscle increased from 0.50 to 0.85, corresponding to the largest dynamic range between normal and stage 3. The accuracy, sensitivity, and specificity of diagnosing walking function were 85.52%, 76.31%, and 94.73%, respectively. The Nakagami parameter of the rectus femoris and gastrocnemius muscles correlated negatively with the 6-minute walking distance in the ambulatory patients. Therefore, changes in the Nakagami parameter for the gastrocnemius muscle are suitable for monitoring disease progression in ambulatory patients and for predicting ambulation loss. Ultrasound Nakagami imaging shows potential for evaluating patients with DMD.
format	article
author	Wen-Chin Weng Po-Hsiang Tsui Chia-Wei Lin Chun-Hao Lu Chun-Yen Lin Jeng-Yi Shieh Frank Leigh Lu Ting-Wei Ee Kuan-Wen Wu Wang-Tso Lee
author_facet	Wen-Chin Weng Po-Hsiang Tsui Chia-Wei Lin Chun-Hao Lu Chun-Yen Lin Jeng-Yi Shieh Frank Leigh Lu Ting-Wei Ee Kuan-Wen Wu Wang-Tso Lee
author_sort	Wen-Chin Weng
title	Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
title_short	Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
title_full	Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
title_fullStr	Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
title_full_unstemmed	Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
title_sort	evaluation of muscular changes by ultrasound nakagami imaging in duchenne muscular dystrophy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f1d9b02298cb4b5a9c21cbea2855b7c5
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_version_	1718388554175873024

Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy

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