The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis

Summary: Synaptonemal complex (SC) assembly and homologous recombination, the most critical events during prophase I, are the prerequisite for faithful meiotic chromosome segregation. However, the underlying regulatory mechanism remains largely unknown. Here, we reveal that a functional RING finger...

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Autores principales:	Lijun Ren, Tingting Zhao, Yangzi Zhao, Guijie Du, Shuying Yang, Na Mu, Ding Tang, Yi Shen, Yafei Li, Zhukuan Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	rice ubiquitination meiosis synapsis SC-like polycomplexes crossovers Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f1d9b4ef96e64b4985920e9e7f58d3ca
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spelling	oai:doaj.org-article:f1d9b4ef96e64b4985920e9e7f58d3ca2021-11-04T04:29:32ZThe E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis2211-124710.1016/j.celrep.2021.109941https://doaj.org/article/f1d9b4ef96e64b4985920e9e7f58d3ca2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014145https://doaj.org/toc/2211-1247Summary: Synaptonemal complex (SC) assembly and homologous recombination, the most critical events during prophase I, are the prerequisite for faithful meiotic chromosome segregation. However, the underlying regulatory mechanism remains largely unknown. Here, we reveal that a functional RING finger E3 ubiquitin ligase, DESYNAPSIS1 (DSNP1), plays significant roles in SC assembly and homologous recombination during rice meiosis. In the dsnp1 mutant, homologous synapsis is discontinuous and aberrant SC-like polycomplexes occur independent of coaligned homologous chromosomes. Accompanying the decreased foci of HEI10, ZIP4, and MER3 on meiotic chromosomes, the number of crossovers (COs) decreases dramatically in dsnp1 meiocytes. Furthermore, the absence of central elements largely restores the localization of non-ZEP1 ZMM proteins and the number of COs in the dsnp1 background. Collectively, DSNP1 stabilizes the canonical tripartite SC structure along paired homologous chromosomes and further promotes the formation of COs.Lijun RenTingting ZhaoYangzi ZhaoGuijie DuShuying YangNa MuDing TangYi ShenYafei LiZhukuan ChengElsevierarticlericeubiquitinationmeiosissynapsisSC-like polycomplexescrossoversBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109941- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rice ubiquitination meiosis synapsis SC-like polycomplexes crossovers Biology (General) QH301-705.5
spellingShingle	rice ubiquitination meiosis synapsis SC-like polycomplexes crossovers Biology (General) QH301-705.5 Lijun Ren Tingting Zhao Yangzi Zhao Guijie Du Shuying Yang Na Mu Ding Tang Yi Shen Yafei Li Zhukuan Cheng The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
description	Summary: Synaptonemal complex (SC) assembly and homologous recombination, the most critical events during prophase I, are the prerequisite for faithful meiotic chromosome segregation. However, the underlying regulatory mechanism remains largely unknown. Here, we reveal that a functional RING finger E3 ubiquitin ligase, DESYNAPSIS1 (DSNP1), plays significant roles in SC assembly and homologous recombination during rice meiosis. In the dsnp1 mutant, homologous synapsis is discontinuous and aberrant SC-like polycomplexes occur independent of coaligned homologous chromosomes. Accompanying the decreased foci of HEI10, ZIP4, and MER3 on meiotic chromosomes, the number of crossovers (COs) decreases dramatically in dsnp1 meiocytes. Furthermore, the absence of central elements largely restores the localization of non-ZEP1 ZMM proteins and the number of COs in the dsnp1 background. Collectively, DSNP1 stabilizes the canonical tripartite SC structure along paired homologous chromosomes and further promotes the formation of COs.
format	article
author	Lijun Ren Tingting Zhao Yangzi Zhao Guijie Du Shuying Yang Na Mu Ding Tang Yi Shen Yafei Li Zhukuan Cheng
author_facet	Lijun Ren Tingting Zhao Yangzi Zhao Guijie Du Shuying Yang Na Mu Ding Tang Yi Shen Yafei Li Zhukuan Cheng
author_sort	Lijun Ren
title	The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
title_short	The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
title_full	The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
title_fullStr	The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
title_full_unstemmed	The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis
title_sort	e3 ubiquitin ligase desynapsis1 regulates synapsis and recombination in rice meiosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f1d9b4ef96e64b4985920e9e7f58d3ca
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The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis

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