Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases

Berberine has lipid-lowering effects and other metabolic benefits, but it presents with poor bioavailability. Here the authors conjugate berberine to liver-targeting nanoparticles, and show increased accumulation of berberine in the liver, improved metabolic profiles and reduced atherosclerotic plaq...

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Autores principales:	Hui-Hui Guo, Chen-Lin Feng, Wen-Xuan Zhang, Zhi-Gang Luo, Hong-Juan Zhang, Ting-Ting Zhang, Chen Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang, Wen-Sheng Zheng, Yan-Xing Han, Jian-Dong Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1dbe28cac9f4edfac9a5a63a81b496e
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spelling	oai:doaj.org-article:f1dbe28cac9f4edfac9a5a63a81b496e2021-12-02T15:36:18ZLiver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases10.1038/s41467-019-09852-02041-1723https://doaj.org/article/f1dbe28cac9f4edfac9a5a63a81b496e2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09852-0https://doaj.org/toc/2041-1723Berberine has lipid-lowering effects and other metabolic benefits, but it presents with poor bioavailability. Here the authors conjugate berberine to liver-targeting nanoparticles, and show increased accumulation of berberine in the liver, improved metabolic profiles and reduced atherosclerotic plaques in mice.Hui-Hui GuoChen-Lin FengWen-Xuan ZhangZhi-Gang LuoHong-Juan ZhangTing-Ting ZhangChen MaYun ZhanRui LiSong WuZeper AblizCong LiXiao-Lin LiXiao-Lei MaLu-Lu WangWen-Sheng ZhengYan-Xing HanJian-Dong JiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui-Hui Guo Chen-Lin Feng Wen-Xuan Zhang Zhi-Gang Luo Hong-Juan Zhang Ting-Ting Zhang Chen Ma Yun Zhan Rui Li Song Wu Zeper Abliz Cong Li Xiao-Lin Li Xiao-Lei Ma Lu-Lu Wang Wen-Sheng Zheng Yan-Xing Han Jian-Dong Jiang Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
description	Berberine has lipid-lowering effects and other metabolic benefits, but it presents with poor bioavailability. Here the authors conjugate berberine to liver-targeting nanoparticles, and show increased accumulation of berberine in the liver, improved metabolic profiles and reduced atherosclerotic plaques in mice.
format	article
author	Hui-Hui Guo Chen-Lin Feng Wen-Xuan Zhang Zhi-Gang Luo Hong-Juan Zhang Ting-Ting Zhang Chen Ma Yun Zhan Rui Li Song Wu Zeper Abliz Cong Li Xiao-Lin Li Xiao-Lei Ma Lu-Lu Wang Wen-Sheng Zheng Yan-Xing Han Jian-Dong Jiang
author_facet	Hui-Hui Guo Chen-Lin Feng Wen-Xuan Zhang Zhi-Gang Luo Hong-Juan Zhang Ting-Ting Zhang Chen Ma Yun Zhan Rui Li Song Wu Zeper Abliz Cong Li Xiao-Lin Li Xiao-Lei Ma Lu-Lu Wang Wen-Sheng Zheng Yan-Xing Han Jian-Dong Jiang
author_sort	Hui-Hui Guo
title	Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
title_short	Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
title_full	Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
title_fullStr	Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
title_full_unstemmed	Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
title_sort	liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f1dbe28cac9f4edfac9a5a63a81b496e
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Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases

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