Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
Hydroxycarboxylic acid receptor 3 (HCA<sub>3</sub>) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA<sub>3</sub> ligands by <i>Bifidobacterium</i> spp. In addition to 4-hydroxyphenyllac...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f1df41a4e22944bbbe2069ede95f2049 |
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| Sumario: | Hydroxycarboxylic acid receptor 3 (HCA<sub>3</sub>) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA<sub>3</sub> ligands by <i>Bifidobacterium</i> spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by <i>Bifidobacterium</i> as an HCA<sub>3</sub> ligand. The four ligands produced were the mixtures of enantiomers, and D-ILA, D-PLA, and D-LeuA showed stronger activity of the HCA<sub>3</sub> ligand than their respective L-isomers. However, there was no difference in AhR activity between the two ILA enantiomers. These results provide new insights into the HCA<sub>3</sub> ligands produced by <i>Bifidobacterium</i> and suggest the importance of investigating the absolute stereo structures of these metabolites. |
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