Production of Hydroxycarboxylic Acid Receptor 3 (HCA3) Ligands by Bifidobacterium

Hydroxycarboxylic acid receptor 3 (HCA3) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA3 ligands by Bifidobacterium spp. In addition to 4-hydroxyphenyllac...

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Autores principales:	Takuma Sakurai, Ayako Horigome, Toshitaka Odamaki, Takashi Shimizu, Jin-Zhong Xiao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Bifidobacterium</i> indole-3-lactic acid 3-phenyllactic acid 4-hydroxyphenyllactic acid leucic acid hydroxycarboxylic acid receptor 3 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f1df41a4e22944bbbe2069ede95f2049
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spelling	oai:doaj.org-article:f1df41a4e22944bbbe2069ede95f20492021-11-25T18:25:40ZProduction of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>10.3390/microorganisms91123972076-2607https://doaj.org/article/f1df41a4e22944bbbe2069ede95f20492021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2397https://doaj.org/toc/2076-2607Hydroxycarboxylic acid receptor 3 (HCA<sub>3</sub>) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA<sub>3</sub> ligands by <i>Bifidobacterium</i> spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by <i>Bifidobacterium</i> as an HCA<sub>3</sub> ligand. The four ligands produced were the mixtures of enantiomers, and D-ILA, D-PLA, and D-LeuA showed stronger activity of the HCA<sub>3</sub> ligand than their respective L-isomers. However, there was no difference in AhR activity between the two ILA enantiomers. These results provide new insights into the HCA<sub>3</sub> ligands produced by <i>Bifidobacterium</i> and suggest the importance of investigating the absolute stereo structures of these metabolites.Takuma SakuraiAyako HorigomeToshitaka OdamakiTakashi ShimizuJin-Zhong XiaoMDPI AGarticle<i>Bifidobacterium</i>indole-3-lactic acid3-phenyllactic acid4-hydroxyphenyllactic acidleucic acidhydroxycarboxylic acid receptor 3Biology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2397, p 2397 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Bifidobacterium</i> indole-3-lactic acid 3-phenyllactic acid 4-hydroxyphenyllactic acid leucic acid hydroxycarboxylic acid receptor 3 Biology (General) QH301-705.5
spellingShingle	<i>Bifidobacterium</i> indole-3-lactic acid 3-phenyllactic acid 4-hydroxyphenyllactic acid leucic acid hydroxycarboxylic acid receptor 3 Biology (General) QH301-705.5 Takuma Sakurai Ayako Horigome Toshitaka Odamaki Takashi Shimizu Jin-Zhong Xiao Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
description	Hydroxycarboxylic acid receptor 3 (HCA<sub>3</sub>) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA<sub>3</sub> ligands by <i>Bifidobacterium</i> spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by <i>Bifidobacterium</i> as an HCA<sub>3</sub> ligand. The four ligands produced were the mixtures of enantiomers, and D-ILA, D-PLA, and D-LeuA showed stronger activity of the HCA<sub>3</sub> ligand than their respective L-isomers. However, there was no difference in AhR activity between the two ILA enantiomers. These results provide new insights into the HCA<sub>3</sub> ligands produced by <i>Bifidobacterium</i> and suggest the importance of investigating the absolute stereo structures of these metabolites.
format	article
author	Takuma Sakurai Ayako Horigome Toshitaka Odamaki Takashi Shimizu Jin-Zhong Xiao
author_facet	Takuma Sakurai Ayako Horigome Toshitaka Odamaki Takashi Shimizu Jin-Zhong Xiao
author_sort	Takuma Sakurai
title	Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
title_short	Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
title_full	Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
title_fullStr	Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
title_full_unstemmed	Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>
title_sort	production of hydroxycarboxylic acid receptor 3 (hca<sub>3</sub>) ligands by <i>bifidobacterium</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1df41a4e22944bbbe2069ede95f2049
work_keys_str_mv	AT takumasakurai productionofhydroxycarboxylicacidreceptor3hcasub3subligandsbyibifidobacteriumi AT ayakohorigome productionofhydroxycarboxylicacidreceptor3hcasub3subligandsbyibifidobacteriumi AT toshitakaodamaki productionofhydroxycarboxylicacidreceptor3hcasub3subligandsbyibifidobacteriumi AT takashishimizu productionofhydroxycarboxylicacidreceptor3hcasub3subligandsbyibifidobacteriumi AT jinzhongxiao productionofhydroxycarboxylicacidreceptor3hcasub3subligandsbyibifidobacteriumi
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Production of Hydroxycarboxylic Acid Receptor 3 (HCA<sub>3</sub>) Ligands by <i>Bifidobacterium</i>

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