The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital

(1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet con...

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Autores principales:	Roberta Maria Fachini, Rita Fontão-Wendel, Ruth Achkar, Patrícia Scuracchio, Mayra Brito, Marcelo Amaral, Silvano Wendel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pathogen reduction blood safety platelet transfusion INTERCEPT plasma Medicine R
Acceso en línea:	https://doaj.org/article/f1e067b55b944820bca857f867ab3f45
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spelling	oai:doaj.org-article:f1e067b55b944820bca857f867ab3f452021-11-25T18:38:44ZThe 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital10.3390/pathogens101114992076-0817https://doaj.org/article/f1e067b55b944820bca857f867ab3f452021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1499https://doaj.org/toc/2076-0817(1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet concentrate (PC), including pathogen reduced (PR-PC) production, inventory management, discard rates, blood utilization, and clinical outcomes were analyzed over the 40 months before and after PR implementation. Age distribution and wastage rates were compared over the 10 months before and after approval for PR-PC to be stored for up to seven days. (3) Results: A 100% PR-PC inventory was achieved by increasing double apheresis collections and production of double doses using pools of two single apheresis units. Discard rates decreased from 6% to 3% after PR implementation and further decreased to 1.2% after seven-day storage extension for PR-PCs. The blood utilization remained stable, with no increase in component utilization. A significant decrease in adverse transfusion events was observed after the PR implementation. (4) Conclusion: Our experience demonstrates the feasibility for Brazilian blood centers to achieve a 100% PR-PC inventory. All patients at our hospital received PR-PC and showed no increase in blood component utilization and decreased rates of adverse transfusion reactions.Roberta Maria FachiniRita Fontão-WendelRuth AchkarPatrícia ScuracchioMayra BritoMarcelo AmaralSilvano WendelMDPI AGarticlepathogen reductionblood safetyplatelet transfusionINTERCEPTplasmaMedicineRENPathogens, Vol 10, Iss 1499, p 1499 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pathogen reduction blood safety platelet transfusion INTERCEPT plasma Medicine R
spellingShingle	pathogen reduction blood safety platelet transfusion INTERCEPT plasma Medicine R Roberta Maria Fachini Rita Fontão-Wendel Ruth Achkar Patrícia Scuracchio Mayra Brito Marcelo Amaral Silvano Wendel The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
description	(1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet concentrate (PC), including pathogen reduced (PR-PC) production, inventory management, discard rates, blood utilization, and clinical outcomes were analyzed over the 40 months before and after PR implementation. Age distribution and wastage rates were compared over the 10 months before and after approval for PR-PC to be stored for up to seven days. (3) Results: A 100% PR-PC inventory was achieved by increasing double apheresis collections and production of double doses using pools of two single apheresis units. Discard rates decreased from 6% to 3% after PR implementation and further decreased to 1.2% after seven-day storage extension for PR-PCs. The blood utilization remained stable, with no increase in component utilization. A significant decrease in adverse transfusion events was observed after the PR implementation. (4) Conclusion: Our experience demonstrates the feasibility for Brazilian blood centers to achieve a 100% PR-PC inventory. All patients at our hospital received PR-PC and showed no increase in blood component utilization and decreased rates of adverse transfusion reactions.
format	article
author	Roberta Maria Fachini Rita Fontão-Wendel Ruth Achkar Patrícia Scuracchio Mayra Brito Marcelo Amaral Silvano Wendel
author_facet	Roberta Maria Fachini Rita Fontão-Wendel Ruth Achkar Patrícia Scuracchio Mayra Brito Marcelo Amaral Silvano Wendel
author_sort	Roberta Maria Fachini
title	The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
title_short	The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
title_full	The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
title_fullStr	The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
title_full_unstemmed	The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital
title_sort	4-year experience with implementation and routine use of pathogen reduction in a brazilian hospital
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1e067b55b944820bca857f867ab3f45
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The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital

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