Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice

Human mesenchymal stromal cells are a promising source for cell-based therapies. Here the authors use Cas9 to engineer lines that secrete PDGF-BB and VEFGA for improving wound healing.

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Autores principales:	Waracharee Srifa, Nina Kosaric, Alvaro Amorin, Othmane Jadi, Yujin Park, Sruthi Mantri, Joab Camarena, Geoffrey C. Gurtner, Matthew Porteus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1e0b2e3490d49f9b4d885258b1c4088
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spelling	oai:doaj.org-article:f1e0b2e3490d49f9b4d885258b1c40882021-12-02T15:45:13ZCas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice10.1038/s41467-020-16065-32041-1723https://doaj.org/article/f1e0b2e3490d49f9b4d885258b1c40882020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16065-3https://doaj.org/toc/2041-1723Human mesenchymal stromal cells are a promising source for cell-based therapies. Here the authors use Cas9 to engineer lines that secrete PDGF-BB and VEFGA for improving wound healing.Waracharee SrifaNina KosaricAlvaro AmorinOthmane JadiYujin ParkSruthi MantriJoab CamarenaGeoffrey C. GurtnerMatthew PorteusNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Waracharee Srifa Nina Kosaric Alvaro Amorin Othmane Jadi Yujin Park Sruthi Mantri Joab Camarena Geoffrey C. Gurtner Matthew Porteus Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
description	Human mesenchymal stromal cells are a promising source for cell-based therapies. Here the authors use Cas9 to engineer lines that secrete PDGF-BB and VEFGA for improving wound healing.
format	article
author	Waracharee Srifa Nina Kosaric Alvaro Amorin Othmane Jadi Yujin Park Sruthi Mantri Joab Camarena Geoffrey C. Gurtner Matthew Porteus
author_facet	Waracharee Srifa Nina Kosaric Alvaro Amorin Othmane Jadi Yujin Park Sruthi Mantri Joab Camarena Geoffrey C. Gurtner Matthew Porteus
author_sort	Waracharee Srifa
title	Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
title_short	Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
title_full	Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
title_fullStr	Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
title_full_unstemmed	Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
title_sort	cas9-aav6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f1e0b2e3490d49f9b4d885258b1c4088
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Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice

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